Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study.
| dc.contributor.author | Li, YJ | |
| dc.contributor.author | Martin, ER | |
| dc.contributor.author | Zhang, L | |
| dc.contributor.author | Allen, AS | |
| dc.coverage.spatial | England | |
| dc.date.accessioned | 2015-09-21T01:08:52Z | |
| dc.date.issued | 2005-12-30 | |
| dc.description.abstract | Association studies of quantitative traits have often relied on methods in which a normal distribution of the trait is assumed. However, quantitative phenotypes from complex human diseases are often censored, highly skewed, or contaminated with outlying values. We recently developed a rank-based association method that takes into account censoring and makes no distributional assumptions about the trait. In this study, we applied our new method to age-at-onset data on ALDX1 and ALDX2. Both traits are highly skewed (skewness > 1.9) and often censored. We performed a whole genome association study of age at onset of the ALDX1 trait using Illumina single-nucleotide polymorphisms. Only slightly more than 5% of markers were significant. However, we identified two regions on chromosomes 14 and 15, which each have at least four significant markers clustering together. These two regions may harbor genes that regulate age at onset of ALDX1 and ALDX2. Future fine mapping of these two regions with densely spaced markers is warranted. | |
| dc.identifier | ||
| dc.identifier | 1471-2156-6-S1-S53 | |
| dc.identifier.eissn | 1471-2156 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | BMC Genet | |
| dc.relation.isversionof | 10.1186/1471-2156-6-S1-S53 | |
| dc.subject | Adult | |
| dc.subject | Age of Onset | |
| dc.subject | Alcoholism | |
| dc.subject | Chromosomes, Human, Pair 14 | |
| dc.subject | Chromosomes, Human, Pair 15 | |
| dc.subject | Cooperative Behavior | |
| dc.subject | Databases, Genetic | |
| dc.subject | Genetic Markers | |
| dc.subject | Genetic Predisposition to Disease | |
| dc.subject | Genetic Testing | |
| dc.subject | Humans | |
| dc.subject | Models, Genetic | |
| dc.title | Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Li, YJ|0000-0001-6996-4834 | |
| duke.contributor.orcid | Allen, AS|0000-0002-7232-2143 | |
| pubs.author-url | ||
| pubs.begin-page | S53 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | School of Medicine | |
| pubs.publication-status | Published online | |
| pubs.volume | 6 Suppl 1 |
Files
Original bundle
- Name:
- Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study..pdf
- Size:
- 238.41 KB
- Format:
- Adobe Portable Document Format