Predictive model for achieving good clinical and radiographic outcomes at one-year following surgical correction of adult cervical deformity.
| dc.contributor.author | Passias, Peter Gust | |
| dc.contributor.author | Horn, Samantha R | |
| dc.contributor.author | Oh, Cheongeun | |
| dc.contributor.author | Poorman, Gregory W | |
| dc.contributor.author | Bortz, Cole | |
| dc.contributor.author | Segreto, Frank | |
| dc.contributor.author | Lafage, Renaud | |
| dc.contributor.author | Diebo, Bassel | |
| dc.contributor.author | Scheer, Justin K | |
| dc.contributor.author | Smith, Justin S | |
| dc.contributor.author | Shaffrey, Christopher I | |
| dc.contributor.author | Eastlack, Robert | |
| dc.contributor.author | Sciubba, Daniel M | |
| dc.contributor.author | Protopsaltis, Themistocles | |
| dc.contributor.author | Kim, Han Jo | |
| dc.contributor.author | Hart, Robert A | |
| dc.contributor.author | Lafage, Virginie | |
| dc.contributor.author | Ames, Christopher P | |
| dc.contributor.author | International Spine Study Group | |
| dc.date.accessioned | 2023-06-16T16:51:34Z | |
| dc.date.available | 2023-06-16T16:51:34Z | |
| dc.date.issued | 2021-07 | |
| dc.date.updated | 2023-06-16T16:51:33Z | |
| dc.description.abstract | BackgroundFor cervical deformity (CD) surgery, goals include realignment, improved patient quality of life, and improved clinical outcomes. There is limited research identifying patients most likely to achieve all three.ObjectiveThe objective is to create a model predicting good 1-year postoperative realignment, quality of life, and clinical outcomes following CD surgery using baseline demographic, clinical, and radiographic factors.MethodsRetrospective review of a multicenter CD database. CD patients were defined as having one of the following radiographic criteria: Cervical sagittal vertical axis (cSVA) >4 cm, cervical kyphosis/scoliosis >10°° or chin-brow vertical angle >25°. The outcome assessed was whether a patient achieved both a good radiographic and clinical outcome. The primary analysis was stepwise regression models which generated a dataset-specific prediction model for achieving a good radiographic and clinical outcome. Model internal validation was achieved by bootstrapping and calculating the area under the curve (AUC) of the final model with 95% confidence intervals.ResultsSeventy-three CD patients were included (61.8 years, 58.9% F). The final model predicting the achievement of a good overall outcome (radiographic and clinical) yielded an AUC of 73.5% and included the following baseline demographic, clinical, and radiographic factors: mild-moderate myelopathy (Modified Japanese Orthopedic Association >12), no pedicle subtraction osteotomy, no prior cervical spine surgery, posterior lowest instrumented vertebra (LIV) at T1 or above, thoracic kyphosis >33°°, T1 slope <16 and cSVA <20 mm.ConclusionsAchievement of a positive outcome in radiographic and clinical outcomes following surgical correction of CD can be predicted with high accuracy using a combination of demographic, clinical, radiographic, and surgical factors, with the top factors being baseline cSVA <20 mm, no prior cervical surgery, and posterior LIV at T1 or above. | |
| dc.identifier | JCVJS-12-228 | |
| dc.identifier.issn | 0974-8237 | |
| dc.identifier.issn | 0976-9285 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Medknow | |
| dc.relation.ispartof | Journal of craniovertebral junction & spine | |
| dc.relation.isversionof | 10.4103/jcvjs.jcvjs_40_21 | |
| dc.subject | International Spine Study Group | |
| dc.title | Predictive model for achieving good clinical and radiographic outcomes at one-year following surgical correction of adult cervical deformity. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Passias, Peter Gust|0000-0002-1479-4070|0000-0003-2635-2226 | |
| duke.contributor.orcid | Shaffrey, Christopher I|0000-0001-9760-8386 | |
| pubs.begin-page | 228 | |
| pubs.end-page | 235 | |
| pubs.issue | 3 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Orthopaedic Surgery | |
| pubs.organisational-group | Neurosurgery | |
| pubs.publication-status | Published | |
| pubs.volume | 12 |
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