Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014.
dc.contributor.author | Pisharody, Sruti | |
dc.contributor.author | Rubach, Matthew P | |
dc.contributor.author | Carugati, Manuela | |
dc.contributor.author | Nicholson, William L | |
dc.contributor.author | Perniciaro, Jamie L | |
dc.contributor.author | Biggs, Holly M | |
dc.contributor.author | Maze, Michael J | |
dc.contributor.author | Hertz, Julian T | |
dc.contributor.author | Halliday, Jo EB | |
dc.contributor.author | Allan, Kathryn J | |
dc.contributor.author | Mmbaga, Blandina T | |
dc.contributor.author | Saganda, Wilbrod | |
dc.contributor.author | Lwezaula, Bingileki F | |
dc.contributor.author | Kazwala, Rudovick R | |
dc.contributor.author | Cleaveland, Sarah | |
dc.contributor.author | Maro, Venance P | |
dc.contributor.author | Crump, John A | |
dc.date.accessioned | 2024-01-25T16:57:27Z | |
dc.date.available | 2024-01-25T16:57:27Z | |
dc.date.issued | 2021-12 | |
dc.description.abstract | Q fever and spotted fever group rickettsioses (SFGR) are common causes of severe febrile illness in northern Tanzania. Incidence estimates are needed to characterize the disease burden. Using hybrid surveillance-coupling case-finding at two referral hospitals and healthcare utilization data-we estimated the incidences of acute Q fever and SFGR in Moshi, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014. Cases were defined as fever and a four-fold or greater increase in antibody titers of acute and convalescent paired sera according to the indirect immunofluorescence assay of Coxiella burnetii phase II antigen for acute Q fever and Rickettsia conorii (2007-2008) or Rickettsia africae (2012-2014) antigens for SFGR. Healthcare utilization data were used to adjust for underascertainment of cases by sentinel surveillance. For 2007 to 2008, among 589 febrile participants, 16 (4.7%) of 344 and 27 (8.8%) of 307 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 80 (uncertainty range, 20-454) and 147 (uncertainty range, 52-645) per 100,000 persons, respectively. For 2012 to 2014, among 1,114 febrile participants, 52 (8.1%) and 57 (8.9%) of 641 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 56 (uncertainty range, 24-163) and 75 (uncertainty range, 34-176) per 100,000 persons, respectively. We found substantial incidences of acute Q fever and SFGR in northern Tanzania during both study periods. To our knowledge, these are the first incidence estimates of either disease in sub-Saharan Africa. Our findings suggest that control measures for these infections warrant consideration. | |
dc.identifier | tpmd201036 | |
dc.identifier.issn | 0002-9637 | |
dc.identifier.issn | 1476-1645 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | American Society of Tropical Medicine and Hygiene | |
dc.relation.ispartof | The American journal of tropical medicine and hygiene | |
dc.relation.isversionof | 10.4269/ajtmh.20-1036 | |
dc.rights.uri | ||
dc.subject | Humans | |
dc.subject | Q Fever | |
dc.subject | Incidence | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Infant | |
dc.subject | Delivery of Health Care | |
dc.subject | Tanzania | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Spotted Fever Group Rickettsiosis | |
dc.title | Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014. | |
dc.type | Journal article | |
duke.contributor.orcid | Carugati, Manuela|0000-0002-3187-5905 | |
duke.contributor.orcid | Hertz, Julian T|0000-0002-7396-4789 | |
duke.contributor.orcid | Mmbaga, Blandina T|0000-0002-5550-1916 | |
duke.contributor.orcid | Crump, John A|0000-0002-4529-102X | |
pubs.begin-page | 494 | |
pubs.end-page | 503 | |
pubs.issue | 2 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke University | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Duke Global Health Institute | |
pubs.organisational-group | Emergency Medicine | |
pubs.publication-status | Published | |
pubs.volume | 106 |
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