Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014.

dc.contributor.author

Pisharody, Sruti

dc.contributor.author

Rubach, Matthew P

dc.contributor.author

Carugati, Manuela

dc.contributor.author

Nicholson, William L

dc.contributor.author

Perniciaro, Jamie L

dc.contributor.author

Biggs, Holly M

dc.contributor.author

Maze, Michael J

dc.contributor.author

Hertz, Julian T

dc.contributor.author

Halliday, Jo EB

dc.contributor.author

Allan, Kathryn J

dc.contributor.author

Mmbaga, Blandina T

dc.contributor.author

Saganda, Wilbrod

dc.contributor.author

Lwezaula, Bingileki F

dc.contributor.author

Kazwala, Rudovick R

dc.contributor.author

Cleaveland, Sarah

dc.contributor.author

Maro, Venance P

dc.contributor.author

Crump, John A

dc.date.accessioned

2024-01-25T16:57:27Z

dc.date.available

2024-01-25T16:57:27Z

dc.date.issued

2021-12

dc.description.abstract

Q fever and spotted fever group rickettsioses (SFGR) are common causes of severe febrile illness in northern Tanzania. Incidence estimates are needed to characterize the disease burden. Using hybrid surveillance-coupling case-finding at two referral hospitals and healthcare utilization data-we estimated the incidences of acute Q fever and SFGR in Moshi, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014. Cases were defined as fever and a four-fold or greater increase in antibody titers of acute and convalescent paired sera according to the indirect immunofluorescence assay of Coxiella burnetii phase II antigen for acute Q fever and Rickettsia conorii (2007-2008) or Rickettsia africae (2012-2014) antigens for SFGR. Healthcare utilization data were used to adjust for underascertainment of cases by sentinel surveillance. For 2007 to 2008, among 589 febrile participants, 16 (4.7%) of 344 and 27 (8.8%) of 307 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 80 (uncertainty range, 20-454) and 147 (uncertainty range, 52-645) per 100,000 persons, respectively. For 2012 to 2014, among 1,114 febrile participants, 52 (8.1%) and 57 (8.9%) of 641 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 56 (uncertainty range, 24-163) and 75 (uncertainty range, 34-176) per 100,000 persons, respectively. We found substantial incidences of acute Q fever and SFGR in northern Tanzania during both study periods. To our knowledge, these are the first incidence estimates of either disease in sub-Saharan Africa. Our findings suggest that control measures for these infections warrant consideration.

dc.identifier

tpmd201036

dc.identifier.issn

0002-9637

dc.identifier.issn

1476-1645

dc.identifier.uri

https://hdl.handle.net/10161/29832

dc.language

eng

dc.publisher

American Society of Tropical Medicine and Hygiene

dc.relation.ispartof

The American journal of tropical medicine and hygiene

dc.relation.isversionof

10.4269/ajtmh.20-1036

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Humans

dc.subject

Q Fever

dc.subject

Incidence

dc.subject

Adolescent

dc.subject

Adult

dc.subject

Aged

dc.subject

Aged, 80 and over

dc.subject

Middle Aged

dc.subject

Child

dc.subject

Child, Preschool

dc.subject

Infant

dc.subject

Delivery of Health Care

dc.subject

Tanzania

dc.subject

Female

dc.subject

Male

dc.subject

Young Adult

dc.subject

Spotted Fever Group Rickettsiosis

dc.title

Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014.

dc.type

Journal article

duke.contributor.orcid

Carugati, Manuela|0000-0002-3187-5905

duke.contributor.orcid

Hertz, Julian T|0000-0002-7396-4789

duke.contributor.orcid

Mmbaga, Blandina T|0000-0002-5550-1916

duke.contributor.orcid

Crump, John A|0000-0002-4529-102X

pubs.begin-page

494

pubs.end-page

503

pubs.issue

2

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke University

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Medicine

pubs.organisational-group

Medicine, Infectious Diseases

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Duke Global Health Institute

pubs.organisational-group

Emergency Medicine

pubs.publication-status

Published

pubs.volume

106

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and fro.pdf
Size:
830.01 KB
Format:
Adobe Portable Document Format