Age-related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging.

dc.contributor.author

Bennett, Ilana J

dc.contributor.author

Madden, David J

dc.contributor.author

Vaidya, Chandan J

dc.contributor.author

Howard, Darlene V

dc.contributor.author

Howard, James H

dc.date.accessioned

2025-04-01T15:42:56Z

dc.date.available

2025-04-01T15:42:56Z

dc.date.issued

2010-03

dc.description.abstract

Diffusion tensor imaging (DTI) measures diffusion of molecular water, which can be used to calculate indices of white matter integrity. Early DTI studies of aging primarily focused on two global measures of integrity; the average rate (mean diffusivity, MD) and orientation coherence (fractional anisotropy, FA) of diffusion. More recent studies have added measures of water movement parallel (axial diffusivity, AD) and perpendicular (radial diffusivity, RD) to the primary diffusion direction, which are thought to reflect the neural bases of age differences in diffusion (i.e., axonal shrinkage and demyelination, respectively). In this study, patterns of age differences in white matter integrity were assessed by comparing younger and healthy older adults on multiple measures of integrity (FA, AD, and RD). Results revealed two commonly reported patterns (Radial Increase Only and Radial/Axial Increase), and one relatively novel pattern (Radial Increase/Axial Decrease) that varied by brain region and may reflect differential aging of microstructural (e.g., degree of myelination) and macrostructural (e.g., coherence of fiber orientation) properties of white matter. In addition, larger age differences in FA in frontal white matter were consistent with the anterior-posterior gradient of age differences in white matter integrity. Together, these findings complement other recent studies in providing information about patterns of diffusivity that are characteristic of healthy aging.

dc.identifier.issn

1065-9471

dc.identifier.issn

1097-0193

dc.identifier.uri

https://hdl.handle.net/10161/32175

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

Human brain mapping

dc.relation.isversionof

10.1002/hbm.20872

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Brain

dc.subject

Nerve Fibers, Myelinated

dc.subject

Humans

dc.subject

Neuropsychological Tests

dc.subject

Health Status

dc.subject

Aging

dc.subject

Anisotropy

dc.subject

Adolescent

dc.subject

Aged

dc.subject

Middle Aged

dc.subject

Female

dc.subject

Male

dc.subject

Young Adult

dc.subject

Diffusion Tensor Imaging

dc.title

Age-related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging.

dc.type

Journal article

duke.contributor.orcid

Madden, David J|0000-0003-2815-6552

pubs.begin-page

378

pubs.end-page

390

pubs.issue

3

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Psychiatry & Behavioral Sciences

pubs.organisational-group

Psychology & Neuroscience

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Center for Cognitive Neuroscience

pubs.organisational-group

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

pubs.publication-status

Published

pubs.volume

31

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Age-related differences in multiple measures of white matter integrity A diffusion tensor imaging study of healthy aging.pdf
Size:
248.82 KB
Format:
Adobe Portable Document Format
Description:
Published version