Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.

Ryser, MD

McGoff, K

Herzog, DP

Sivakoff, DJ

Myers, ER

Netherlands

2015-03-11T20:37:28Z

2015-06

The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, several empirical studies on HPV immunization have been published, providing evidence of the fact that marginal vaccination costs increase with coverage. In this study, we use a stochastic agent-based modeling framework to revisit the male vaccination debate in light of these new findings. Within this framework, we assess the impact of coverage-dependent marginal costs of vaccine distribution on optimal immunization strategies against HPV. Focusing on the two scenarios of ongoing and new vaccination programs, we analyze different resource allocation policies and their effects on overall disease burden. Our results suggest that if the costs associated with vaccinating males are relatively close to those associated with vaccinating females, then coverage-dependent, increasing marginal costs may favor vaccination strategies that entail immunization of both genders. In particular, this study emphasizes the necessity for further empirical research on the nature of coverage-dependent vaccination costs.

http://www.ncbi.nlm.nih.gov/pubmed/25979280

S1755-4365(15)00005-5

1878-0067

https://hdl.handle.net/10161/9500

eng

Elsevier BV

Epidemics

10.1016/j.epidem.2015.01.003

Human papillomavirus vaccination

Male HPV vaccination

Marginal distribution costs

Optimal vaccine distribution

Stochastic agent-based models

Adolescent

Cohort Studies

Cost-Benefit Analysis

Female

Health Care Rationing

Human papillomavirus 16

Humans

Immunization Programs

Male

Papillomavirus Infections

Papillomavirus Vaccines

Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/25979280

32

47

Clinical Science Departments

Duke

Duke Cancer Institute

Duke Clinical Research Institute

Gynecology

Institutes and Centers

Obstetrics

Obstetrics and Gynecology

School of Medicine

Staff

Published

11