D-Dimer elevation and adverse outcomes.
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2015-01
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Abstract
D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adverse outcomes has received far less emphasis. An elevated D-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated D-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the D-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.
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Halaby, Rim, Christopher J Popma, Ander Cohen, Gerald Chi, Marcelo Rodrigues Zacarkim, Gonzalo Romero, Samuel Z Goldhaber, Russell Hull, et al. (2015). D-Dimer elevation and adverse outcomes. J Thromb Thrombolysis, 39(1). pp. 55–59. 10.1007/s11239-014-1101-6 Retrieved from https://hdl.handle.net/10161/13934.
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