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Relation between BMI and diabetes mellitus and its complications among US older adults.

dc.contributor.author Gray, N
dc.contributor.author Picone, Gabriel A
dc.contributor.author Sloan, Frank A
dc.contributor.author Yashkin, Arseniy
dc.coverage.spatial United States
dc.date.accessioned 2017-06-05T17:59:45Z
dc.date.available 2017-06-05T17:59:45Z
dc.date.issued 2015-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/25580754
dc.identifier SMJ14164
dc.identifier.uri https://hdl.handle.net/10161/14808
dc.description.abstract OBJECTIVES: This study examined relations between elevated body mass index (BMI) and time to diagnosis with type 2 diabetes mellitus and its complications among older adults in the United States. METHODS: Data came from the Medicare Current Beneficiary Survey, 1991-2010. A Cox proportional hazard model was used to assess relations between excess BMI at the first Medicare Current Beneficiary Survey interview and time to diabetes mellitus diagnosis, complications, and insulin dependence among Medicare beneficiaries, older than 65 years of age with no prior diabetes mellitus diagnosis, and who were not enrolled in Medicare Advantage (N = 14,657). RESULTS: Among individuals diagnosed as having diabetes mellitus, elevated BMIs were associated with a progressively higher risk of complications from diabetes mellitus. For women with a BMI ≥40, the risk of insulin dependence (hazard ratio [HR] 3.57; 95% confidence interval [CI] 2.36-5.39) was twice that for women with 25 ≤ BMI < 27.5 (HR 1.77; 95% CI 1.33-2.33). A similar pattern was observed in risk of cardiovascular (25 ≤ BMI < 27.5: HR 1.34; 95% CI 1.15-1.54; BMI ≥40: HR 2.45; 95% CI 1.92-3.11), cerebrovascular (25 ≤ BMI < 27.5: HR 1.30; 95% CI 1.06-1.57; BMI ≥40: HR 2.00; 95% CI 1.42-2.81), renal (25 ≤ BMI < 27.5: HR 1.31; 95% CI 1.04-1.63; BMI ≥40: HR 2.23; 95% CI 1.54-3.22), and lower extremity complications (25 ≤ BMI < 27.5: HR 1.41; 95% CI 1.22-1.61; BMI ≥40: HR 2.95; 95% CI 2.35-3.69). CONCLUSIONS: Any increase in BMI above normal weight levels is associated with an increased risk of being diagnosed as having complications of diabetes mellitus. For men, the increased risk of these complications occurred at higher BMI levels than in women. Ocular complications occurred at higher BMI levels than other complication types in both men and women.
dc.language eng
dc.relation.ispartof South Med J
dc.relation.isversionof 10.14423/SMJ.0000000000000214
dc.subject Aged
dc.subject Body Mass Index
dc.subject Cardiovascular Diseases
dc.subject Cerebrovascular Disorders
dc.subject Diabetes Mellitus, Type 2
dc.subject Diabetic Foot
dc.subject Diabetic Nephropathies
dc.subject Diabetic Retinopathy
dc.subject Female
dc.subject Humans
dc.subject Hypertension
dc.subject Male
dc.subject Obesity
dc.subject Overweight
dc.subject Proportional Hazards Models
dc.subject United States
dc.title Relation between BMI and diabetes mellitus and its complications among US older adults.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/25580754
pubs.begin-page 29
pubs.end-page 36
pubs.issue 1
pubs.organisational-group Center for Child and Family Policy
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Economics
pubs.organisational-group Nursing
pubs.organisational-group Sanford
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Nursing
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 108
dc.identifier.eissn 1541-8243


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