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Functional connectivity in the retina at the resolution of photoreceptors.

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Date
2010-10
Authors
Field, Greg D
Gauthier, Jeffrey L
Sher, Alexander
Greschner, Martin
Machado, Timothy A
Jepson, Lauren H
Shlens, Jonathon
Gunning, Deborah E
Mathieson, Keith
Dabrowski, Wladyslaw
Paninski, Liam
Litke, Alan M
Chichilnisky, EJ
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(13 total)
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Abstract
To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications of these for colour vision. Multi-electrode technology was used to record simultaneously from complete populations of the retinal ganglion cell types (midget, parasol and small bistratified) that transmit high-resolution visual signals to the brain. Fine-grained visual stimulation was used to identify the location, type and strength of the functional input of each cone photoreceptor to each ganglion cell. The populations of ON and OFF midget and parasol cells each sampled the complete population of long- and middle-wavelength-sensitive cones. However, only OFF midget cells frequently received strong input from short-wavelength-sensitive cones. ON and OFF midget cells showed a small non-random tendency to selectively sample from either long- or middle-wavelength-sensitive cones to a degree not explained by clumping in the cone mosaic. These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons.
Type
Journal article
Subject
Neural Pathways
Retinal Ganglion Cells
Animals
Macaca
Macaca fascicularis
Macaca mulatta
Photic Stimulation
Color Perception
Light
Color
Models, Neurological
Retinal Cone Photoreceptor Cells
Color Vision
Permalink
https://hdl.handle.net/10161/17861
Published Version (Please cite this version)
10.1038/nature09424
Publication Info
Field, Greg D; Gauthier, Jeffrey L; Sher, Alexander; Greschner, Martin; Machado, Timothy A; Jepson, Lauren H; ... Chichilnisky, EJ (2010). Functional connectivity in the retina at the resolution of photoreceptors. Nature, 467(7316). pp. 673-677. 10.1038/nature09424. Retrieved from https://hdl.handle.net/10161/17861.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Field

Greg D. Field

Associate Professor of Neurobiology
My laboratory studies how the retina processes visual scenes and transmits this information to the brain.  We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms a
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