Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.
Abstract
Since androgen receptor (AR) signaling is critically required for the development
of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice
for advanced and metastatic PCa. Unfortunately, although the tumor initially responds
to the therapy, treatment resistance eventually develops and the disease will progress.
It is therefore imperative to identify the mechanisms of therapeutic resistance and
novel molecular targets that are independent of AR signaling. Recent advances in pathology,
molecular biology, genetics and genomics research have revealed novel AR-independent
pathways that contribute to PCa carcinogenesis and progression. They include neuroendocrine
differentiation, cell metabolism, DNA damage repair pathways and immune-mediated mechanisms.
The development of novel agents targeting the non-AR mechanisms holds great promise
to treat PCa that does not respond to AR-targeted therapies.
Type
Journal articleSubject
Androgen receptorCancer metabolism
DNA damage repair
Neuroendocrine
Prostate cancer
Therapeutic resistance
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https://hdl.handle.net/10161/18631Published Version (Please cite this version)
10.1016/j.ajur.2018.11.002Publication Info
Xu, Lingfan; Chen, Junyi; Liu, Weipeng; Liang, Chaozhao; Hu, Hailiang; & Huang, Jiaoti (2019). Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.
Asian journal of urology, 6(1). pp. 91-98. 10.1016/j.ajur.2018.11.002. Retrieved from https://hdl.handle.net/10161/18631.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Hailiang Hu
Assistant Professor of Pathology
Jiaoti Huang
Endowed Department Chair of Pathology
I am a physician-scientist with clinical expertise in the pathologic diagnosis of
genitourinary tumors including tumors of the prostate, bladder, kidney and testis.
Another area of interest is gynecologic tumors. In my research laboratory we study
prostate cancer, focusing on molecular mechanisms of carcinogenesis and tumor progression,
as well as biomarkers, imaging and novel therapeutic strategies. In addition to patient
care and research, I am also passionate about education. I have trained n
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