The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.
Abstract
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily
of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range
of cellular processes, including cell proliferation, differentiation, survival, apoptosis,
and inflammation. Dysregulation of JNK pathway is associated with a wide range of
immune disorders and cancer. Our objective is to provide a review of JNK proteins
and their upstream regulators and downstream effector molecules in common skin disorders,
including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous
cell carcinoma (SCC), and melanoma.
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https://hdl.handle.net/10161/23887Published Version (Please cite this version)
10.3390/cells9040857Publication Info
(2020). The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer. Cells, 9(4). pp. 857-857. 10.3390/cells9040857. Retrieved from https://hdl.handle.net/10161/23887.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Jennifer Yunyan Zhang
Professor in Dermatology
Epidermis of the skin constitutes the largest organ and the outer most barrier of
the body. It is one of the few organs that undergo lifelong self-renewal through a
tight balance of cell growth, differentiation, and programmed cell death. Deregulation
of this balance is manifested in many diseases, including various immune diseases
and cancer.
Our lab is focused on 3 interrelated topics:
1. Gene regulation of epithelial cell proliferation and differenti
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