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The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.

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Date
2020-04-02
Authors
Hammouda, Manel B
Ford, Amy E
Liu, Yuan
Zhang, Jennifer Y
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Abstract
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
Type
Journal article
Subject
Humans
Neoplasms
Skin Diseases
JNK Mitogen-Activated Protein Kinases
Signal Transduction
Permalink
https://hdl.handle.net/10161/23887
Published Version (Please cite this version)
10.3390/cells9040857
Publication Info
Hammouda, Manel B; Ford, Amy E; Liu, Yuan; & Zhang, Jennifer Y (2020). The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer. Cells, 9(4). pp. 857-857. 10.3390/cells9040857. Retrieved from https://hdl.handle.net/10161/23887.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Zhang

Jennifer Yunyan Zhang

Professor in Dermatology
Epidermis of the skin constitutes the largest organ and the outer most barrier of the body. It is one of the few organs that undergo lifelong self-renewal through a tight balance of cell growth, differentiation, and programmed cell death. Deregulation of this balance is manifested in many diseases, including various immune diseases and cancer.  Our lab is focused on 3 interrelated topics: 1. Gene regulation of epithelial cell proliferation and differenti
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