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Plasmonic gold nanostars for synergistic photoimmunotherapy to treat cancer

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Date
2021-09-02
Authors
Liu, Yang
Chorniak, Ericka
Odion, Ren
Etienne, Wiguins
Nair, Smita K
Maccarini, Paolo
Palmer, Gregory M
Inman, Brant A
Vo-Dinh, Tuan
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Abstract
Cancer is the second leading cause of death and there is an urgent need to improve cancer management. We have developed an innovative cancer therapy named Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) by combining gold nanostars (GNS)-mediated photothermal ablation with checkpoint inhibitor immunotherapy. Our previous studies have demonstrated that SYMPHONY photoimmunotherapy not only treats the primary tumor but also dramatically amplifies anticancer immune responses in synergy with checkpoint blockade immunotherapy to treat remote and unresectable cancer metastasis. The SYMPHONY treatment also induces a 'cancer vaccine' effect leading to immunologic memory and prevents cancer recurrence in murine animal models. This manuscript provides an overview of our research activities on the SYMPHONY therapy with plasmonic GNS for cancer treatment.
Type
Journal article
Subject
cancer
gold nanostars
photoimmunotherapy
Permalink
https://hdl.handle.net/10161/24170
Published Version (Please cite this version)
10.1515/nanoph-2021-0237
Publication Info
Liu, Yang; Chorniak, Ericka; Odion, Ren; Etienne, Wiguins; Nair, Smita K; Maccarini, Paolo; ... Vo-Dinh, Tuan (2021). Plasmonic gold nanostars for synergistic photoimmunotherapy to treat cancer. Nanophotonics, 10(12). pp. 3295-3302. 10.1515/nanoph-2021-0237. Retrieved from https://hdl.handle.net/10161/24170.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Inman

Brant Allen Inman

Professor of Surgery
Clinical research interests: Clinical trials of novel diagnostic tests and therapies for genitourinary malignancies, with a strong focus on bladder cancer. Basic science research interests: Immune therapies for cancer, hyperthermia and heat-based treatment of cancer, molecular biology of genitourinary cancers, novel diagnostics and therapies for genitourinary cancers
Maccarini

Paolo F Maccarini

Associate Research Professor in the Department of Electrical and Computer Engineering
Nair

Smita K Nair

Professor in Surgery
I have 22 years of experience in the field of cancer vaccines and immunotherapy and I am an accomplished T cell immunologist. Laboratory website:https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory Current projects in the Nair Laboratory:1] Dendritic cell vaccines using tumor-antigen encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)<br
Palmer

Gregory M. Palmer

Associate Professor of Radiation Oncology
Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University in 2000, after which he obtained his Ph.D. in BME from the University of Wisconsin, Madison. He is currently an Associate Professor in the Department of Radiation Oncology, Cancer Biology Division at Duke University Medical Center. His primary research focus has been identifying and exploiting the changes in absorption, scattering, and fluorescence properties of tissue associated with cancer progression and therape
Vo-Dinh

Tuan Vo-Dinh

R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
Dr. Tuan Vo-Dinh is R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering, Professor of Chemistry, and Director of The Fitzpatrick Institute for Photonics. Dr. Vo-Dinh’s research activities and interests involve biophotonics, nanophotonics, plasmonics, laser-excited luminescence spectroscopy, room temperature phosphorimetry, synchronous luminescence spectroscopy, and surface-enhanced Raman spectroscopy for multi-modality bioimaging, and theranostics (d
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