Plasmonic gold nanostars for synergistic photoimmunotherapy to treat cancer
Abstract
Cancer is the second leading cause of death and there is an urgent need to improve
cancer management. We have developed an innovative cancer therapy named Synergistic
Immuno Photothermal Nanotherapy (SYMPHONY) by combining gold nanostars (GNS)-mediated
photothermal ablation with checkpoint inhibitor immunotherapy. Our previous studies
have demonstrated that SYMPHONY photoimmunotherapy not only treats the primary tumor
but also dramatically amplifies anticancer immune responses in synergy with checkpoint
blockade immunotherapy to treat remote and unresectable cancer metastasis. The SYMPHONY
treatment also induces a 'cancer vaccine' effect leading to immunologic memory and
prevents cancer recurrence in murine animal models. This manuscript provides an overview
of our research activities on the SYMPHONY therapy with plasmonic GNS for cancer treatment.
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https://hdl.handle.net/10161/24170Published Version (Please cite this version)
10.1515/nanoph-2021-0237Publication Info
(2021). Plasmonic gold nanostars for synergistic photoimmunotherapy to treat cancer. Nanophotonics, 10(12). pp. 3295-3302. 10.1515/nanoph-2021-0237. Retrieved from https://hdl.handle.net/10161/24170.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Brant Allen Inman
Professor of Surgery
Clinical research interests: Clinical trials of novel diagnostic tests and therapies
for genitourinary malignancies, with a strong focus on bladder cancer. Basic science
research interests: Immune therapies for cancer, hyperthermia and heat-based treatment
of cancer, molecular biology of genitourinary cancers, novel diagnostics and therapies
for genitourinary cancers
Paolo F Maccarini
Assistant Research Professor in the Department of Electrical and Computer Engineering
Smita K Nair
Professor in Surgery
I have 22 years of experience in the field of cancer vaccines and immunotherapy and
I am an accomplished T cell immunologist. Laboratory website:https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory
Current projects in the Nair Laboratory:1] Dendritic cell vaccines using tumor-antigen
encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)<br
Gregory M. Palmer
Associate Professor of Radiation Oncology
Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University
in 2000, after which he obtained his Ph.D. in BME from the University of Wisconsin,
Madison. He is currently an Associate Professor in the Department of Radiation Oncology,
Cancer Biology Division at Duke University Medical Center. His primary research focus
has been identifying and exploiting the changes in absorption, scattering, and fluorescence
properties of tissue associated with cancer progression and therape
Tuan Vo-Dinh
R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
Dr. Tuan Vo-Dinh is R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical
Engineering, Professor of Chemistry, and Director of The Fitzpatrick Institute for
Photonics.
Dr. Vo-Dinh’s research activities and interests involve biophotonics, nanophotonics,
plasmonics, laser-excited luminescence spectroscopy, room temperature phosphorimetry,
synchronous luminescence spectroscopy, and surface-enhanced Raman spectroscopy for
multi-modality bioimaging, and theranostics (d
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