Gold(I)-Catalyzed Amination of Allylic Alcohols with Cyclic Ureas and Related Nucleophiles
Abstract
A 1:1 mixture of [P(t-Bu)(2)-o-biphenyl]AuCl and AgSbF6 catalyzes the Intermolecular
amination of allylic alcohols with 1-methylimidazolidin-2-one and related nucleophiles
that, in the case of gamma-unsubstituted or gamma-methyl-substituted allylic alcohols,
occurs with high gamma-regloselectivity and syn-stereoselectivity.
Type
Other articleSubject
catalyzed direct aminationtitanium(iv) isopropoxide
neutral
conditions
secondary-amines
palladium
allylation
complexes
efficient
alkylation
ligands
chemistry, organic
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https://hdl.handle.net/10161/4110Published Version (Please cite this version)
10.1021/ol902923eCitation
Mukherjee,Paramita;Widenhoefer,Ross A.. 2010. Gold(I)-Catalyzed Amination of Allylic
Alcohols with Cyclic Ureas and Related Nucleophiles. Organic letters 12(6): 1184-1187.
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Show full item recordScholars@Duke
Ross A. Widenhoefer
Professor of Chemistry
Research in the Widenhoefer group is directed toward the development and mechanistic
analysis of new organotransition metal-catalyzed transformations for application in
the synthesis of functionalized organic molecules. In particular, our group has a
long-standing interest in the functionalization of C–C multiple bonds with carbon
and heteroatom nucleophiles catalyzed by electrophilic late transition metal complexes,
with a recent focus on the synthetic and mechanistic aspect of gold(I) pi-acti
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