dc.contributor.author |
Isamah, Nneka |
|
dc.contributor.author |
Faison, Warachal |
|
dc.contributor.author |
Payne, Martha E |
|
dc.contributor.author |
MacFall, James |
|
dc.contributor.author |
Steffens, David C |
|
dc.contributor.author |
Beyer, John L |
|
dc.contributor.author |
Krishnan, K Ranga |
|
dc.contributor.author |
Taylor, Warren D |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:32:20Z |
|
dc.date.issued |
2010-10-26 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/21049028 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4581 |
|
dc.description.abstract |
BACKGROUND: Variation in brain structure is both genetically and environmentally influenced.
The question about potential differences in brain anatomy across populations of differing
race and ethnicity remains a controversial issue. There are few studies specifically
examining racial or ethnic differences and also few studies that test for race-related
differences in context of other neuropsychiatric research, possibly due to the underrepresentation
of ethnic minorities in clinical research. It is within this context that we conducted
a secondary data analysis examining volumetric MRI data from healthy participants
and compared the volumes of the amygdala, hippocampus, lateral ventricles, caudate
nucleus, orbitofrontal cortex (OFC) and total cerebral volume between Caucasian and
African-American participants. We discuss the importance of this finding in context
of neuroimaging methodology, but also the need for improved recruitment of African
Americans in clinical research and its broader implications for a better understanding
of the neural basis of neuropsychiatric disorders. METHODOLOGY/PRINCIPAL FINDINGS:
This was a case control study in the setting of an academic medical center outpatient
service. Participants consisted of 44 Caucasians and 33 ethnic minorities. The following
volumetric data were obtained: amygdala, hippocampus, lateral ventricles, caudate
nucleus, orbitofrontal cortex (OFC) and total cerebrum. Each participant completed
a 1.5 T magnetic resonance imaging (MRI). Our primary finding in analyses of brain
subregions was that when compared to Caucasians, African Americans exhibited larger
left OFC volumes (F (1,68) = 7.50, p = 0.008). CONCLUSIONS: The biological implications
of our findings are unclear as we do not know what factors may be contributing to
these observed differences. However, this study raises several questions that have
important implications for the future of neuropsychiatric research.
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.publisher |
Public Library of Science (PLoS) |
|
dc.relation.ispartof |
PLoS One |
|
dc.relation.isversionof |
10.1371/journal.pone.0013642 |
|
dc.subject |
Adult |
|
dc.subject |
African Americans |
|
dc.subject |
Biomedical Research |
|
dc.subject |
Female |
|
dc.subject |
Frontal Lobe |
|
dc.subject |
Humans |
|
dc.subject |
Magnetic Resonance Imaging |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Patient Selection |
|
dc.subject |
Temporal Lobe |
|
dc.title |
Variability in frontotemporal brain structure: the importance of recruitment of African
Americans in neuroscience research.
|
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Payne, Martha E|0037664 |
|
duke.contributor.id |
MacFall, James|0113645 |
|
duke.contributor.id |
Steffens, David C|0117291 |
|
duke.contributor.id |
Beyer, John L|0169147 |
|
duke.contributor.id |
Krishnan, K Ranga|0068873 |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-10-26 |
|
duke.description.issue |
10 |
|
duke.description.volume |
5 |
|
dc.relation.journal |
Plos One |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/21049028 |
|
pubs.begin-page |
e13642 |
|
pubs.issue |
10 |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke-UNC Center for Brain Imaging and Analysis |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences, Geriatric Behavioral Health |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences, Translational Neuroscience |
|
pubs.organisational-group |
Radiology |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Staff |
|
pubs.publication-status |
Published online |
|
pubs.volume |
5 |
|
dc.identifier.eissn |
1932-6203 |
|