dc.contributor.author |
Chang, AS |
|
dc.contributor.author |
Bennett, SM |
|
dc.contributor.author |
Noor, MAF |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:32:21Z |
|
dc.date.issued |
2010-10-27 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/21060872 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4589 |
|
dc.description.abstract |
The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from
genetic changes that accumulate during population divergence. Indeed, much effort
in recent years has been devoted to identifying genes associated with hybrid incompatibilities,
often with limited success, suggesting that hybrid sterility and inviability are frequently
caused by complex interactions between multiple loci and not by single or a small
number of gene pairs. Our previous study showed that the nature of epistasis between
sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species
pair is highly specific. Here, we further dissect one of the three QTL underlying
hybrid male sterility between these species and provide evidence for multiple factors
within this QTL. This result indicates that the number of loci thought to contribute
to hybrid dysfunction may have been underestimated, and we discuss how linkage and
complex epistasis may be characteristic of the genetics of hybrid incompatibilities.
We further pinpoint the location of one locus that confers hybrid male sterility when
homozygous, dubbed "mule-like", to roughly 250 kilobases.
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.publisher |
Public Library of Science (PLoS) |
|
dc.relation.ispartof |
PLoS One |
|
dc.relation.isversionof |
10.1371/journal.pone.0015377 |
|
dc.subject |
Animals |
|
dc.subject |
Chromosome Mapping |
|
dc.subject |
Drosophila |
|
dc.subject |
Epistasis, Genetic |
|
dc.subject |
Infertility, Male |
|
dc.subject |
Male |
|
dc.subject |
Quantitative Trait Loci |
|
dc.title |
Epistasis among Drosophila persimilis factors conferring hybrid male sterility with
D. pseudoobscura bogotana.
|
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Noor, MAF|0330154 |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-10-27 |
|
duke.description.issue |
10 |
|
duke.description.volume |
5 |
|
dc.relation.journal |
Plos One |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/21060872 |
|
pubs.begin-page |
e15377 |
|
pubs.issue |
10 |
|
pubs.organisational-group |
Biology |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.publication-status |
Published online |
|
pubs.volume |
5 |
|
dc.identifier.eissn |
1932-6203 |
|