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Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.

dc.contributor.author Chang, Audrey S
dc.contributor.author Bennett, Sarah M
dc.contributor.author Noor, Mohamed AF
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:21Z
dc.date.issued 2010-10-27
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21060872
dc.identifier.uri https://hdl.handle.net/10161/4589
dc.description.abstract The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggesting that hybrid sterility and inviability are frequently caused by complex interactions between multiple loci and not by single or a small number of gene pairs. Our previous study showed that the nature of epistasis between sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species pair is highly specific. Here, we further dissect one of the three QTL underlying hybrid male sterility between these species and provide evidence for multiple factors within this QTL. This result indicates that the number of loci thought to contribute to hybrid dysfunction may have been underestimated, and we discuss how linkage and complex epistasis may be characteristic of the genetics of hybrid incompatibilities. We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases.
dc.language eng
dc.language.iso en_US
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0015377
dc.subject Animals
dc.subject Chromosome Mapping
dc.subject Drosophila
dc.subject Epistasis, Genetic
dc.subject Infertility, Male
dc.subject Male
dc.subject Quantitative Trait Loci
dc.title Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
dc.title.alternative
dc.type Journal article
duke.contributor.id Noor, Mohamed AF|0330154
dc.description.version Version of Record
duke.date.pubdate 2010-10-27
duke.description.issue 10
duke.description.volume 5
dc.relation.journal Plos One
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21060872
pubs.begin-page e15377
pubs.issue 10
pubs.organisational-group Biology
pubs.organisational-group Duke
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203


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