Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale.

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2021-07

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Abstract

Objectives

Transcranial electrical stimulation (tES) is a promising tool for modulating neural activity, but tES has poor penetrability and spatiotemporal resolution compared to invasive techniques like deep brain stimulation (DBS). Interferential strategies for alternating-current stimulation (IF-tACS) and pulsed/intersectional strategies for transcranial direct-current stimulation (IS-tDCS) address some of the limitations of tES, but the comparative advantages and disadvantages of these new techniques is not well understood. This study's objective was to evaluate the suprathreshold and subthreshold membrane dynamics of neurons in response to IF-tACS and IS-tDCS.

Materials and methods

We analyzed the biophysics of IF-tACS and IS-tDCS using a bioelectric field model of tES. Neural responses were quantified for suprathreshold generation of action potentials in axons and for subthreshold modulation of membrane dynamics in spiking pyramidal neurons.

Results

IF-tACS and IS-tDCS could not directly activate axons at or below 10 mA, but within this current range, these fields were able to modulate, albeit indirectly, spiking activity in the neuron model. IF-tACS facilitated phase synchronization similar to tACS, and IS-tDCS enhanced and suppressed spiking activity similar to tDCS; however, in either case, the modulatory effects of these fields were less potent than their standard counterparts at a matched field intensity. Moreover, neither IF-tACS nor IS-tDCS improved the spatial selectivity of their parent strategies.

Conclusions

Enhancing the spatiotemporal precision and penetrability of tES with interferential and intersectional strategies is possible at the human scale. However, IF-tACS or IS-tDCS will likely require spatial multiplexing with multiple simultaneous sources to counteract their reduced potency, compared to standard techniques, to maintain stimulation currents at tolerable levels.

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10.1111/ner.13137

Publication Info

Howell, Bryan, and Cameron C McIntyre (2021). Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale. Neuromodulation : journal of the International Neuromodulation Society, 24(5). pp. 843–853. 10.1111/ner.13137 Retrieved from https://hdl.handle.net/10161/23858.

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Scholars@Duke

Howell

Bryan Howell

Assistant Research Professor in the Department of Biomedical Engineering

My lab studies implantable and wearable devices for treating neurological impairment, namely with deep brain stimulation (DBS) and transcranial electrical stimulation (tES). Projects evolve through theoretical and preclinical stages of development, combining biophysical and dynamic causal modeling, medical imaging, and device prototyping, to test new concepts and strategies for these neurotechnologies. Noninvasive studies on tES are conducted in tissue phantoms and healthy human subjects in-house, and we collaborate with physicians to test new concepts in clinical populations.


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