The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis.

Lantos, Paul M

Permar, Sallie R

Hoffman, Kate

Swamy, Geeta K

United States

2016-05-21T20:21:49Z

2015-12

Background.  Cytomegalovirus (CMV) is a common cause of birth defects and hearing loss in infants and opportunistic infections in the immunocompromised. Previous studies have found higher CMV seroprevalence rates among minorities and among persons with lower socioeconomic status. No studies have investigated the geographic distribution of CMV and its relationship to age, race, and poverty in the community. Methods.  We identified patients from 6 North Carolina counties who were tested in the Duke University Health System for CMV immunoglobulin G. We performed spatial statistical analyses to analyze the distributions of seropositive and seronegative individuals. Results.  Of 1884 subjects, 90% were either white or African American. Cytomegalovirus seropositivity was significantly more common among African Americans (73% vs 42%; odds ratio, 3.31; 95% confidence interval, 2.7-4.1), and this disparity persisted across the life span. We identified clusters of high and low CMV odds, both of which were largely explained by race. Clusters of high CMV odds were found in communities with high proportions of African Americans. Conclusions.  Cytomegalovirus seropositivity is geographically clustered, and its distribution is strongly determined by a community's racial composition. African American communities have high prevalence rates of CMV infection, and there may be a disparate burden of CMV-associated morbidity in these communities.

http://www.ncbi.nlm.nih.gov/pubmed/26716106

ofv180

https://hdl.handle.net/10161/12048

eng

Oxford University Press (OUP)

Open Forum Infect Dis

10.1093/ofid/ofv180

African American

cytomegalovirus

disparity

epidemiology

geographic information system

The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis.

Journal article

Hoffman, Kate|0000-0001-8029-7710

Swamy, Geeta K|0000-0001-5092-6993

http://www.ncbi.nlm.nih.gov/pubmed/26716106

ofv180

4

Basic Science Departments

Clinical Science Departments

Duke

Duke Human Vaccine Institute

Global Health Institute

Immunology

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Hospitalists

Midwifery Service

Molecular Genetics and Microbiology

Obstetrics and Gynecology

Obstetrics and Gynecology, Maternal Fetal Medicine

Pediatrics

Pediatrics, Infectious Diseases

School of Medicine

University Institutes and Centers

Published online

2