Association between donor gamete use and supernumerary embryo disposition decisions.

dc.contributor.author

Tsai, Shelun

dc.contributor.author

Hynes, Jenna S

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Zanolli, Nicole

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Raburn, Douglas

dc.contributor.author

Steiner, Anne Z

dc.date.accessioned

2024-05-21T20:23:33Z

dc.date.available

2024-05-21T20:23:33Z

dc.date.issued

2023-02

dc.description.abstract

Purpose

The aim of this study is to determine if donor gamete use is associated with patients' decisions regarding disposition of supernumerary embryos.

Methods

Patients who intended to undergo an IVF cycle at a single academic center signed an embryo disposition consent form to indicate their disposition preferences for any supernumerary embryos. A retrospective chart review was performed to obtain the embryo disposition declarations and demographic information. The primary outcome was the distribution of embryo disposition choices between patients who used donor gametes compared to patients who did not use donor gametes. Fisher's exact test was used to compare groups. Logistic regression models were created to determine the association between donor gamete use and disposition decision after adjusting for patient age, body mass index, and nulliparity.

Results

Five hundred six patients were included. Ninety-one (18.0%) patients used donor gametes [46 (9.0%) donor oocytes, 52 (10.3%) donor sperm]. Patients using donor gametes differed from those not using donor gametes when making decisions concerning death of the patient (P < 0.01), simultaneous death (P = 0.04), separation (P < 0.01), discontinuation of ART (P = 0.01), and time-limited storage (P < 0.01). Most patients, regardless of donor or autologous gamete use, awarded embryos to themselves or their partner if given the option. For patients who did not choose this option, excess embryos were generally awarded to research or discarded rather than donating to another couple. Patients using donor gametes were more likely to award embryos to research over discarding.

Conclusion

Patients using donor gametes made different choices regarding supernumerary embryo disposition compared to patients not using donor gametes.
dc.identifier

10.1007/s10815-022-02690-y

dc.identifier.issn

1058-0468

dc.identifier.issn

1573-7330

dc.identifier.uri

https://hdl.handle.net/10161/30725

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Journal of assisted reproduction and genetics

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10.1007/s10815-022-02690-y

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Germ Cells

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Semen

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Animals

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Fertilization in Vitro

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Retrospective Studies

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Embryo Disposition

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Male

dc.title

Association between donor gamete use and supernumerary embryo disposition decisions.

dc.type

Journal article

duke.contributor.orcid

Raburn, Douglas|0000-0002-7984-1245

pubs.begin-page

371

pubs.end-page

379

pubs.issue

2

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Obstetrics and Gynecology

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Obstetrics and Gynecology, Reproductive Endocrinology & Fertility

pubs.publication-status

Published

pubs.volume

40

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