Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N
| dc.contributor.author | Tawfik, Kamilia A | |
| dc.contributor.author | Jeffs, Peter | |
| dc.contributor.author | Bray, Brian | |
| dc.contributor.author | Dubay, George | |
| dc.contributor.author | Falkinham, Joseph O | |
| dc.contributor.author | Mesbah, Mostafa | |
| dc.contributor.author | Youssef, Diaa | |
| dc.contributor.author | Khalifa, Sherief | |
| dc.contributor.author | Schmidt, Eric W | |
| dc.date.accessioned | 2011-06-21T17:27:11Z | |
| dc.date.available | 2011-06-21T17:27:11Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control. | |
| dc.description.version | Version of Record | |
| dc.identifier.citation | Tawfik,Kamilia A.;Jeffs,Peter;Bray,Brian;Dubay,George;Falkinham,Joseph O.,,III;Mesbah,Mostafa;Youssef,Diaa;Khalifa,Sherief;Schmidt,Eric W.. 2010. Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N. Organic letters 12(4): 664-666. | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.uri | ||
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | |
| dc.relation.isversionof | 10.1021/ol9029269 | |
| dc.relation.journal | Organic letters | |
| dc.subject | amino-acids | |
| dc.subject | identification | |
| dc.subject | cepacia | |
| dc.subject | complex | |
| dc.subject | strain | |
| dc.subject | chemistry, organic | |
| dc.title | Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N | |
| dc.title.alternative | ||
| dc.type | Other article | |
| duke.date.pubdate | 2010-2-19 | |
| duke.description.issue | 4 | |
| duke.description.volume | 12 | |
| pubs.begin-page | 664 | |
| pubs.end-page | 666 |