Organoids as tools for fundamental discovery and translation-a Keystone Symposia report.
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2022-12
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Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving stem cells to differentiate into different organoid types, though several challenges remain. For example, many organoid models suffer from high heterogeneity, and it can be difficult to fully incorporate the complexity of in vivo tissue and organ development to faithfully reproduce human biology. Successfully addressing such limitations would increase the viability of organoids as models for drug development and preclinical testing. On April 3-6, 2022, experts in organoid development and biology convened at the Keystone Symposium "Organoids as Tools for Fundamental Discovery and Translation" to discuss recent advances and insights from this relatively new model system into human development and disease.
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Cable, Jennifer, Matthias P Lutolf, Jianping Fu, Sunghee Estelle Park, Athanasia Apostolou, Shuibing Chen, Cheng Jack Song, Jason R Spence, et al. (2022). Organoids as tools for fundamental discovery and translation-a Keystone Symposia report. Annals of the New York Academy of Sciences, 1518(1). pp. 196–208. 10.1111/nyas.14874 Retrieved from https://hdl.handle.net/10161/31828.
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Samira Musah
The Musah Lab is interested in understanding how molecular signals and biophysical forces can function either synergistically or independently to guide organ development and physiology, and how these processes can be therapeutically harnessed to treat human disease. Given the escalating medical crisis in nephrology as growing number of patients suffer from kidney disease that can lead to organ failure, the Musah Lab focuses on engineering stem cell fate for applications in human kidney disease, extra-renal complications, and therapeutic development. Dr. Musah’s research interests include stem cell biology and regenerative medicine, molecular and cellular basis of human organ development and disease progression, organ engineering, patient-specific disease models, biomarker identification, therapeutic discovery, tissue and organ transplantation, microphysiological systems including Organ Chips (organs-on-chips) and organoids, matrix biology, mechanotransduction and disease biophysics.
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