Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.

Thumbnail Image
View / Download844.97 KB

Date

2020-12

Authors

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

9
views
20
downloads

Citation Stats

Abstract

Background

Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures.

Methods

Using 497 participants from the CATHGEN cohort, we evaluated whether accelerated epigenetic aging increases cardiovascular sensitivity to traffic-related air pollution (TRAP) exposure. We used residential proximity to major roadways and source apportioned air pollution models as measures of TRAP exposure, and chose peripheral arterial disease (PAD) and blood pressure as outcomes based on previous associations with TRAP. We used Horvath epigenetic age acceleration (AAD) and phenotypic age acceleration (PhenoAAD) as measures of age acceleration, and adjusted all models for chronological age, race, sex, smoking, and socioeconomic status.

Results

We observed significant interactions between TRAP and both AAD and PhenoAAD. Interactions indicated that increased epigenetic age acceleration elevated associations between proximity to roadways and PAD. Interactions were also observed between AAD and gasoline and diesel source apportioned PM2.5.

Conclusion

Epigenetic age acceleration may be a biomarker of sensitivity to air pollution, particularly for TRAP in urban cohorts. This presents a novel means by which to understand sensitivity to air pollution and provides a molecular measure of environmental sensitivity.

Type

Journal article

Department

Description

Provenance

Subjects

Humans, Genetic Markers, Risk Assessment, Vehicle Emissions, Environmental Exposure, Environmental Monitoring, Age Factors, Residence Characteristics, DNA Methylation, Epigenesis, Genetic, Aging, Blood Pressure, Aged, Middle Aged, Urban Health, North Carolina, Female, Male, Peripheral Arterial Disease, Traffic-Related Pollution, Heart Disease Risk Factors

Citation

Permalink

https://hdl.handle.net/10161/28583

Published Version (Please cite this version)

10.18632/aging.202341

Publication Info

Ward-Caviness, Cavin K, Armistead G Russell, Anne M Weaver, Erik Slawsky, Radhika Dhingra, Lydia Coulter Kwee, Rong Jiang, Lucas M Neas, et al. (2020). Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. Aging, 12(23). pp. 24141–24155. 10.18632/aging.202341 Retrieved from https://hdl.handle.net/10161/28583.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Collections

Scholarly Articles
Full item page

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.