Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.

Loading...
Thumbnail Image

Date

2019-01

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

92
views
64
downloads

Citation Stats

Abstract

Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although the tumor initially responds to the therapy, treatment resistance eventually develops and the disease will progress. It is therefore imperative to identify the mechanisms of therapeutic resistance and novel molecular targets that are independent of AR signaling. Recent advances in pathology, molecular biology, genetics and genomics research have revealed novel AR-independent pathways that contribute to PCa carcinogenesis and progression. They include neuroendocrine differentiation, cell metabolism, DNA damage repair pathways and immune-mediated mechanisms. The development of novel agents targeting the non-AR mechanisms holds great promise to treat PCa that does not respond to AR-targeted therapies.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1016/j.ajur.2018.11.002

Publication Info

Xu, Lingfan, Junyi Chen, Weipeng Liu, Chaozhao Liang, Hailiang Hu and Jiaoti Huang (2019). Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer. Asian journal of urology, 6(1). pp. 91–98. 10.1016/j.ajur.2018.11.002 Retrieved from https://hdl.handle.net/10161/18631.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.