Three periods of regulatory innovation during vertebrate evolution.
Repository Usage Stats
The gain, loss, and modification of gene regulatory elements may underlie a substantial proportion of phenotypic changes on animal lineages. To investigate the gain of regulatory elements throughout vertebrate evolution, we identified genome-wide sets of putative regulatory regions for five vertebrates, including humans. These putative regulatory regions are conserved nonexonic elements (CNEEs), which are evolutionarily conserved yet do not overlap any coding or noncoding mature transcript. We then inferred the branch on which each CNEE came under selective constraint. Our analysis identified three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
Published Version (Please cite this version)
Lowe, Craig B, Manolis Kellis, Adam Siepel, Brian J Raney, Michele Clamp, Sofie R Salama, David M Kingsley, Kerstin Lindblad-Toh, et al. (2011). Three periods of regulatory innovation during vertebrate evolution. Science (New York, N.Y.), 333(6045). pp. 1019–1024. 10.1126/science.1202702 Retrieved from https://hdl.handle.net/10161/17403.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.