Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells
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2017-08-01
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© 2017 Elsevier Ltd Obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. Here, we report a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. The model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with gold nanoshells in order to be heated quickly. The proposed model is implemented numerically using a stable finite difference scheme. The method is demonstrated and tested by an example.
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Orndorff, C, S Ponomarev, W Dai and A Bejan (2017). Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells. International Journal of Heat and Mass Transfer, 111. pp. 677–695. 10.1016/j.ijheatmasstransfer.2017.04.024 Retrieved from https://hdl.handle.net/10161/15195.
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