Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells

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2017-08-01

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Abstract

© 2017 Elsevier Ltd Obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. Here, we report a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. The model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with gold nanoshells in order to be heated quickly. The proposed model is implemented numerically using a stable finite difference scheme. The method is demonstrated and tested by an example.

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10.1016/j.ijheatmasstransfer.2017.04.024

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Orndorff, C, S Ponomarev, W Dai and A Bejan (2017). Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells. International Journal of Heat and Mass Transfer, 111. pp. 677–695. 10.1016/j.ijheatmasstransfer.2017.04.024 Retrieved from https://hdl.handle.net/10161/15195.

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Bejan

Adrian Bejan

J.A. Jones Distinguished Professor of Mechanical Engineering

Professor Bejan was awarded the Benjamin Franklin Medal 2018 and the Humboldt Research Award 2019. His research covers engineering science and applied physics: thermodynamics, heat transfer, convection, design, and evolution in nature.

He is ranked among the top 0.01% of the most cited and impactful world scientists (and top 10 in Engineering world wide) in the 2019 citations impact database created by Stanford University’s John Ioannidis, in PLoS Biology.  He is the author of 30 books and 700 peer-referred articles. His h-index is 111 with 92,000 citations on Google Scholar. He received 18 honorary doctorates from universities in 11 countries.


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