Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.
dc.contributor.author | Clyde, Merlise A | |
dc.contributor.author | Palmieri Weber, Rachel | |
dc.contributor.author | Iversen, Edwin S | |
dc.contributor.author | Poole, Elizabeth M | |
dc.contributor.author | Doherty, Jennifer A | |
dc.contributor.author | Goodman, Marc T | |
dc.contributor.author | Ness, Roberta B | |
dc.contributor.author | Risch, Harvey A | |
dc.contributor.author | Rossing, Mary Anne | |
dc.contributor.author | Terry, Kathryn L | |
dc.contributor.author | Wentzensen, Nicolas | |
dc.contributor.author | Whittemore, Alice S | |
dc.contributor.author | Anton-Culver, Hoda | |
dc.contributor.author | Bandera, Elisa V | |
dc.contributor.author | Berchuck, Andrew | |
dc.contributor.author | Carney, Michael E | |
dc.contributor.author | Cramer, Daniel W | |
dc.contributor.author | Cunningham, Julie M | |
dc.contributor.author | Cushing-Haugen, Kara L | |
dc.contributor.author | Edwards, Robert P | |
dc.contributor.author | Fridley, Brooke L | |
dc.contributor.author | Goode, Ellen L | |
dc.contributor.author | Lurie, Galina | |
dc.contributor.author | McGuire, Valerie | |
dc.contributor.author | Modugno, Francesmary | |
dc.contributor.author | Moysich, Kirsten B | |
dc.contributor.author | Olson, Sara H | |
dc.contributor.author | Pearce, Celeste Leigh | |
dc.contributor.author | Pike, Malcolm C | |
dc.contributor.author | Rothstein, Joseph H | |
dc.contributor.author | Sellers, Thomas A | |
dc.contributor.author | Sieh, Weiva | |
dc.contributor.author | Stram, Daniel | |
dc.contributor.author | Thompson, Pamela J | |
dc.contributor.author | Vierkant, Robert A | |
dc.contributor.author | Wicklund, Kristine G | |
dc.contributor.author | Wu, Anna H | |
dc.contributor.author | Ziogas, Argyrios | |
dc.contributor.author | Tworoger, Shelley S | |
dc.contributor.author | Schildkraut, Joellen M | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2016-10-06T18:30:37Z | |
dc.date.issued | 2016-10-15 | |
dc.description.abstract | Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Because of this, we developed and internally validated a relative risk prediction model that incorporates 17 established epidemiologic risk factors and 17 genome-wide significant single nucleotide polymorphisms (SNPs) using data from 11 case-control studies in the United States (5,793 cases; 9,512 controls) from the Ovarian Cancer Association Consortium (data accrued from 1992 to 2010). We developed a hierarchical logistic regression model for predicting case-control status that included imputation of missing data. We randomly divided the data into an 80% training sample and used the remaining 20% for model evaluation. The AUC for the full model was 0.664. A reduced model without SNPs performed similarly (AUC = 0.649). Both models performed better than a baseline model that included age and study site only (AUC = 0.563). The best predictive power was obtained in the full model among women younger than 50 years of age (AUC = 0.714); however, the addition of SNPs increased the AUC the most for women older than 50 years of age (AUC = 0.638 vs. 0.616). Adapting this improved model to estimate absolute risk and evaluating it in prospective data sets is warranted. | |
dc.identifier | ||
dc.identifier | kww091 | |
dc.identifier.eissn | 1476-6256 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartof | Am J Epidemiol | |
dc.relation.isversionof | 10.1093/aje/kww091 | |
dc.subject | genetic risk polymorphisms | |
dc.subject | model evaluation | |
dc.subject | ovarian cancer | |
dc.subject | risk model | |
dc.title | Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci. | |
dc.type | Journal article | |
duke.contributor.orcid | Clyde, Merlise A|0000-0002-3595-1872 | |
duke.contributor.orcid | Iversen, Edwin S|0000-0002-0066-2763 | |
pubs.author-url | ||
pubs.begin-page | 579 | |
pubs.end-page | 589 | |
pubs.issue | 8 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Obstetrics and Gynecology | |
pubs.organisational-group | Obstetrics and Gynecology, Gynecologic Oncology | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Statistical Science | |
pubs.organisational-group | Trinity College of Arts & Sciences | |
pubs.publication-status | Published | |
pubs.volume | 184 |
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