Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch.

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2015-10-15

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Abstract

Notch signaling is implicated in prostate cancer progression and docetaxel resistance. Cui and colleagues describe the additive efficacy and mechanisms of a γ-secretase inhibitor, PF-03084014, and docetaxel in preclinical models of prostate cancer, suggesting the need for further clinical development of Notch pathway modulators in men with metastatic prostate cancer.

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Journal article

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Amyloid Precursor Protein Secretases, Animals, Antineoplastic Combined Chemotherapy Protocols, Humans, Male, Prostatic Neoplasms

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https://hdl.handle.net/10161/10916

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10.1158/1078-0432.CCR-15-1613

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Zhang, Tian, and Andrew J Armstrong (2015). Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch. Clin Cancer Res, 21(20). pp. 4505–4507. 10.1158/1078-0432.CCR-15-1613 Retrieved from https://hdl.handle.net/10161/10916.

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Zhang

Tian Zhang

Adjunct Associate Professor in the Department of Medicine

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