On-line adaptive radiation therapy: feasibility and clinical study.
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2010-01
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The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT imaging and fast volumetric reoptimization of treatment plans. A fast intensity-modulated radiotherapy (IMRT) plan reoptimization algorithm is implemented and evaluated with clinical cases. The quality of these adapted plans is compared to the corresponding new plans generated by an experienced planner using a commercial treatment planning system and also evaluated by an in-house developed tool estimating achievable dose-volume histograms (DVHs) based on a database of existing treatment plans. In addition, a clinical implementation scheme for ART is designed and evaluated using clinical cases for its dosimetric qualities and efficiency.
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Li, Taoran, Xiaofeng Zhu, Danthai Thongphiew, W Robert Lee, Zeljko Vujaskovic, Qiuwen Wu, Fang-Fang Yin, Q Jackie Wu, et al. (2010). On-line adaptive radiation therapy: feasibility and clinical study. Journal of oncology, 2010. p. 407236. 10.1155/2010/407236 Retrieved from https://hdl.handle.net/10161/21119.
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W. Robert Lee
Prostate cancer, Intensity-modulated radiation therapy (IMRT), Image-guided radiation therapy (IGRT), Stereotactic Body Radiation Therapy (SBRT), Prostate HDR and LDR Brachytherapy, Quality of Life, Educational Technology
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