Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.
dc.contributor.author | Sun, Jessica M | |
dc.contributor.author | Grant, Gerald A | |
dc.contributor.author | McLaughlin, Colleen | |
dc.contributor.author | Allison, June | |
dc.contributor.author | Fitzgerald, Anne | |
dc.contributor.author | Waters-Pick, Barbara | |
dc.contributor.author | Kurtzberg, Joanne | |
dc.date.accessioned | 2022-03-23T19:17:22Z | |
dc.date.available | 2022-03-23T19:17:22Z | |
dc.date.issued | 2015-12 | |
dc.date.updated | 2022-03-23T19:17:22Z | |
dc.description.abstract | BackgroundBabies with congenital hydrocephalus often experience developmental disabilities due to brain injury associated with prolonged increased pressure on the developing brain parenchyma. Umbilical cord blood (CB) infusion has favorable effects in animal models of brain hypoxia and stroke and is being investigated in clinical trials of brain injury in both children and adults. We sought to establish the safety and feasibility of repeated intravenous infusions of autologous CB in young babies with congenital hydrocephalus.MethodsInfants with severe congenital hydrocephalus and an available qualified autologous CB unit traveled to Duke for evaluation and CB infusion. When possible, the CB unit was utilized for multiple infusions. Patient and CB data were obtained at the time of infusion and analyzed retrospectively.ResultsFrom October 2006 to August 2014, 76 patients with congenital hydrocephalus received 143 autologous CB infusions. Most babies received repeated doses, for a total of two (n = 45), three (n = 18), or four (n = 4) infusions. There were no infusion-related adverse events. As expected, all babies experienced developmental delays.ConclusionCryopreserved CB products may be effectively manipulated to provide multiple CB doses. Repeated intravenous infusion of autologous CB is safe and feasible in young babies with congenital hydrocephalus. | |
dc.identifier | pr2015161 | |
dc.identifier.issn | 0031-3998 | |
dc.identifier.issn | 1530-0447 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Pediatric research | |
dc.relation.isversionof | 10.1038/pr.2015.161 | |
dc.subject | Humans | |
dc.subject | Hydrocephalus | |
dc.subject | Treatment Outcome | |
dc.subject | Reoperation | |
dc.subject | Cord Blood Stem Cell Transplantation | |
dc.subject | Transplantation, Autologous | |
dc.subject | Retrospective Studies | |
dc.subject | Feasibility Studies | |
dc.subject | Developmental Disabilities | |
dc.subject | Age Factors | |
dc.subject | Time Factors | |
dc.subject | Child, Preschool | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | North Carolina | |
dc.subject | Female | |
dc.subject | Male | |
dc.title | Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. | |
dc.type | Journal article | |
duke.contributor.orcid | Sun, Jessica M|0000-0001-8085-1013 | |
duke.contributor.orcid | Grant, Gerald A|0000-0002-2651-4603 | |
duke.contributor.orcid | Kurtzberg, Joanne|0000-0002-3370-0703 | |
pubs.begin-page | 712 | |
pubs.end-page | 716 | |
pubs.issue | 6 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Pediatrics | |
pubs.organisational-group | Pediatrics, Hematology-Oncology | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Duke Innovation & Entrepreneurship | |
pubs.organisational-group | Pediatrics, Transplant and Cellular Therapy | |
pubs.publication-status | Published | |
pubs.volume | 78 |
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