Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
| dc.contributor.author | Newman, Anne B | |
| dc.contributor.author | Glynn, Nancy W | |
| dc.contributor.author | Taylor, Christopher A | |
| dc.contributor.author | Sebastiani, Paola | |
| dc.contributor.author | Perls, Thomas T | |
| dc.contributor.author | Mayeux, Richard | |
| dc.contributor.author | Christensen, Kaare | |
| dc.contributor.author | Zmuda, Joseph M | |
| dc.contributor.author | Barral, Sandra | |
| dc.contributor.author | Lee, Joseph H | |
| dc.contributor.author | Simonsick, Eleanor M | |
| dc.contributor.author | Walston, Jeremy D | |
| dc.contributor.author | Yashin, Anatoli I | |
| dc.contributor.author | Hadley, Evan | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2017-06-09T19:47:21Z | |
| dc.date.available | 2017-06-09T19:47:21Z | |
| dc.date.issued | 2011-01 | |
| dc.description.abstract | Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival. | |
| dc.identifier | ||
| dc.identifier | 100242 | |
| dc.identifier.eissn | 1945-4589 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Impact Journals, LLC | |
| dc.relation.ispartof | Aging (Albany NY) | |
| dc.relation.isversionof | 10.18632/aging.100242 | |
| dc.subject | Aged | |
| dc.subject | Aged, 80 and over | |
| dc.subject | Aging | |
| dc.subject | Blood Pressure | |
| dc.subject | Cardiovascular Diseases | |
| dc.subject | Cohort Studies | |
| dc.subject | Female | |
| dc.subject | Gait | |
| dc.subject | Humans | |
| dc.subject | Longevity | |
| dc.subject | Male | |
| dc.subject | Middle Aged | |
| dc.subject | Psychomotor Performance | |
| dc.subject | Research Design | |
| dc.title | Health and function of participants in the Long Life Family Study: A comparison with other cohorts. | |
| dc.type | Journal article | |
| pubs.author-url | ||
| pubs.begin-page | 63 | |
| pubs.end-page | 76 | |
| pubs.issue | 1 | |
| pubs.organisational-group | Center for Population Health & Aging | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Population Research Center | |
| pubs.organisational-group | Duke Population Research Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Social Science Research Institute | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 3 |
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