Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.

Kulminski, Alexander M; Culminskaya, Irina; Ukraintseva, Svetlana V; Arbeev, Konstantin G; Land, Kenneth C; Yashin, Anatoli I

Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.

dc.contributor.author	Kulminski, Alexander M
dc.contributor.author	Culminskaya, Irina
dc.contributor.author	Ukraintseva, Svetlana V
dc.contributor.author	Arbeev, Konstantin G
dc.contributor.author	Land, Kenneth C
dc.contributor.author	Yashin, Anatoli I
dc.coverage.spatial	Ireland
dc.date.accessioned	2017-06-07T19:39:20Z
dc.date.available	2017-06-07T19:39:20Z
dc.date.issued	2010-05
dc.description.abstract	The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.
dc.identifier	https://www.ncbi.nlm.nih.gov/pubmed/20399803
dc.identifier	S0047-6374(10)00072-2
dc.identifier.eissn	1872-6216
dc.identifier.uri	https://hdl.handle.net/10161/14883
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Mech Ageing Dev
dc.relation.isversionof	10.1016/j.mad.2010.04.001
dc.subject	Adolescent
dc.subject	Adult
dc.subject	Aged
dc.subject	Aging
dc.subject	Alleles
dc.subject	Amino Acid Substitution
dc.subject	Cardiovascular Diseases
dc.subject	Child
dc.subject	Child, Preschool
dc.subject	Evolution, Molecular
dc.subject	Female
dc.subject	Health
dc.subject	Humans
dc.subject	Longevity
dc.subject	Male
dc.subject	Middle Aged
dc.subject	Polymorphism, Genetic
dc.subject	Receptors, Adrenergic, beta-2
dc.subject	Risk
dc.subject	Young Adult
dc.title	Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
dc.type	Journal article
duke.contributor.orcid	Arbeev, Konstantin G\|0000-0002-4195-7832
duke.contributor.orcid	Land, Kenneth C\|0000-0002-9551-7314
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/20399803
pubs.begin-page	338
pubs.end-page	345
pubs.issue	5
pubs.organisational-group	Center for Population Health & Aging
pubs.organisational-group	Duke
pubs.organisational-group	Duke Cancer Institute
pubs.organisational-group	Duke Population Research Center
pubs.organisational-group	Duke Population Research Institute
pubs.organisational-group	Institutes and Centers
pubs.organisational-group	Institutes and Provost's Academic Units
pubs.organisational-group	Sanford School of Public Policy
pubs.organisational-group	School of Medicine
pubs.organisational-group	Social Science Research Institute
pubs.organisational-group	Sociology
pubs.organisational-group	Staff
pubs.organisational-group	Trinity College of Arts & Sciences
pubs.organisational-group	University Institutes and Centers
pubs.publication-status	Published
pubs.volume	131

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