Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.

Abstract

The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.

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Citation

Published Version (Please cite this version)

10.1016/j.mad.2010.04.001

Publication Info

Kulminski, Alexander M, Irina Culminskaya, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth C Land and Anatoli I Yashin (2010). Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. Mech Ageing Dev, 131(5). pp. 338–345. 10.1016/j.mad.2010.04.001 Retrieved from https://hdl.handle.net/10161/14883.

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Scholars@Duke

Kulminski

Alexander Kulminski

Research Professor in the Social Science Research Institute
Kulminskaya

Irina Kulminskaya

Research Scientist, Senior

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