Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC
Date
2019-07-31
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Attention Stats
Abstract
<jats:title>Abstract</jats:title> <jats:p>Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.</jats:p>
Type
Department
Description
Provenance
Subjects
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Fast, Olivia G, Brittany Gentry, Liah Strouth, Madison B Niece, Floyd A Beckford and Steven M Shell (2019). Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC. Bioscience Reports, 39(7). 10.1042/bsr20190378 Retrieved from https://hdl.handle.net/10161/21374.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
Floyd A Beckford
Floyd Beckford has a B.Sc. (Hons) in chemistry and a Ph.D. in inorganic chemistry from the University of the West Indies, Jamaica. He was a postdoctoral fellow at Texas A&M University. Before joining Duke Kunshan, he was the Van Daniel Endowed Chair in Chemistry at the University of Virginia’s College, Wise, and previously held faculty positions at Lyon College, Arkansas, and the University of Toledo, Ohio. He was a Fulbright-University of Turku (Finland) Scholar in 2018.
His research focus is the field of medicinal inorganic chemistry. Specifically, he is interested in the potential of transition metal compounds, particularly those of ruthenium, manganese, zinc and copper, to be used as proto-pharmaceuticals. Their use as agents in anticancer, antibacterial, and anti-diabetic chemotherapy is of primary interest. This is a multidisciplinary process involving chemistry, biology and biochemistry. He is also interested in environmental chemistry from the standpoint of Contaminants of Emerging Concern. His teaching interests at Duke Kunshan include inorganic, organic and general chemistry.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.