Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC

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2019-07-31

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<jats:title>Abstract</jats:title> <jats:p>Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.</jats:p>

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10.1042/bsr20190378

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Fast, Olivia G, Brittany Gentry, Liah Strouth, Madison B Niece, Floyd A Beckford and Steven M Shell (2019). Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC. Bioscience Reports, 39(7). 10.1042/bsr20190378 Retrieved from https://hdl.handle.net/10161/21374.

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Beckford

Floyd A Beckford

Professor of Chemistry at Duke Kunshan University

Floyd Beckford has a B.Sc. (Hons) in chemistry and a Ph.D. in inorganic chemistry from the University of the West Indies, Jamaica. He was a postdoctoral fellow at Texas A&M University. Before joining Duke Kunshan, he was the Van Daniel Endowed Chair in Chemistry at the University of Virginia’s College, Wise, and previously held faculty positions at Lyon College, Arkansas, and the University of Toledo, Ohio. He was a Fulbright-University of Turku (Finland) Scholar in 2018.

His research focus is the field of medicinal inorganic chemistry. Specifically, he is interested in the potential of transition metal compounds, particularly those of ruthenium, manganese, zinc and copper, to be used as proto-pharmaceuticals. Their use as agents in anticancer, antibacterial, and anti-diabetic chemotherapy is of primary interest. This is a multidisciplinary process involving chemistry, biology and biochemistry. He is also interested in environmental chemistry from the standpoint of Contaminants of Emerging Concern. His teaching interests at Duke Kunshan include inorganic, organic and general chemistry.


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