Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues

dc.contributor.author

Rajic, Zrinka

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Tovmasyan, Artak

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de Santana, Otávio L

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Peixoto, Isabelle N

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Spasojevic, Ivan

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do Monte, Silmar A

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Ventura, Elizete

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Rebouças, Júlio S

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Batinic-Haberle, Ines

dc.date.accessioned

2020-07-15T22:31:48Z

dc.date.available

2020-07-15T22:31:48Z

dc.date.issued

2017-04-01

dc.date.updated

2020-07-15T22:31:46Z

dc.identifier.issn

0162-0134

dc.identifier.issn

1873-3344

dc.identifier.uri

https://hdl.handle.net/10161/21193

dc.language

English

dc.publisher

Elsevier BV

dc.relation.ispartof

JOURNAL OF INORGANIC BIOCHEMISTRY

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10.1016/j.jinorgbio.2017.01.003

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Science & Technology

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Life Sciences & Biomedicine

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Physical Sciences

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Biochemistry & Molecular Biology

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Chemistry, Inorganic & Nuclear

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Chemistry

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SOD mimics

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Alkoxyalkyl tosylates

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Mn N-alkoxyalkylpyridylporphyrins

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MnTnBuOE-2-PyP5+ (BMX-001)

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MnTTEG-2-PyP5+

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FP-15

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Mechanism of pyridyl nitrogen quatemization

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PEROXYNITRITE DECOMPOSITION CATALYST

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SOD MIMICS

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OXIDATIVE-STRESS

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MANGANESE-PORPHYRIN

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BASIS-SETS

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IN-VIVO

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BIOAVAILABILITY

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MNTE-2-PYP5+

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CHEMISTRY

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ENERGIES

dc.title

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues

dc.type

Journal article

duke.contributor.orcid

Spasojevic, Ivan|0000-0001-9890-6246

pubs.begin-page

50

pubs.end-page

60

pubs.organisational-group

School of Medicine

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Radiation Oncology

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Duke

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Clinical Science Departments

pubs.publication-status

Published

pubs.volume

169

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