Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis.
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2010-11
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OBJECTIVE: To accelerate vein graft reendothelialization and reduce vein graft thrombosis by infusing human umbilical cord blood-derived endothelial cells (hCB-ECs) because loss of endothelium contributes to vein graft thrombosis and neointimal hyperplasia. RESULTS: Under steady flow conditions in vitro, hCB-ECs adhered to smooth muscle cells 2.5 to 13 times more than ECs derived from peripheral blood or human aorta (P
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Brown, MA, L Zhang, VW Levering, JH Wu, LL Satterwhite, L Brian, NJ Freedman, GA Truskey, et al. (2010). Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis. Arteriosclerosis, thrombosis, and vascular biology, 30(11). pp. 2150–2155. 10.1161/ATVBAHA.110.207076 Retrieved from https://hdl.handle.net/10161/31545.
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