Refractory Cytomegalovirus Colitis Followed by <i>De Novo</i> Inflammatory Bowel Disease Post-Orthotopic Liver Transplantation.


Cytomegalovirus (CMV) and inflammatory bowel disease (IBD) are both immune-mediated complications that affect orthotopic liver transplantation patients. In this report, we present a 60-year-old man who underwent orthotopic liver transplantation for cryptogenic cirrhosis with serologies notable for CMV-seropositive donor and seronegative recipient. His post-transplant course was initially complicated by probable refractory CMV colitis. However, his gastrointestinal symptoms persisted, eventually leading to a diagnosis of post-transplant de novo IBD. The discussion highlights theories regarding the association between CMV and IBD, a topic that has been widely debated for decades.





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Publication Info

Selvan, Bharathi, Avani A Pendse, Cecelia Zhang, Jeffriann Cauthen, Matthew R Kappus and Julia A Messina (2023). Refractory Cytomegalovirus Colitis Followed by De Novo Inflammatory Bowel Disease Post-Orthotopic Liver Transplantation. ACG case reports journal, 10(12). p. e01232. 10.14309/crj.0000000000001232 Retrieved from

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Avani Anil Pendse

Associate Professor of Pathology

Matthew Robert Kappus

Associate Professor of Medicine

Julia Antoinette Messina

Assistant Professor of Medicine

I am a Transplant Infectious Diseases Physician who specializes in the care of immunocompromised patients including solid organ and bone marrow transplant recipients and patients with HIV. My research interests are in infections and clinical outcomes in patients with hematologic malignancies.

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