In vivo small animal micro-CT using nanoparticle contrast agents.
| dc.contributor.author | Ashton, Jeffrey R | |
| dc.contributor.author | West, Jennifer L | |
| dc.contributor.author | Badea, Cristian T | |
| dc.coverage.spatial | Switzerland | |
| dc.date.accessioned | 2015-12-02T20:58:57Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Computed tomography (CT) is one of the most valuable modalities for in vivo imaging because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily used not only in the clinic (for both diagnostics and treatment planning) but also in preclinical research as micro-CT. Although CT is inherently effective for lung and bone imaging, soft tissue imaging requires the use of contrast agents. For small animal micro-CT, nanoparticle contrast agents are used in order to avoid rapid renal clearance. A variety of nanoparticles have been used for micro-CT imaging, but the majority of research has focused on the use of iodine-containing nanoparticles and gold nanoparticles. Both nanoparticle types can act as highly effective blood pool contrast agents or can be targeted using a wide variety of targeting mechanisms. CT imaging can be further enhanced by adding spectral capabilities to separate multiple co-injected nanoparticles in vivo. Spectral CT, using both energy-integrating and energy-resolving detectors, has been used with multiple contrast agents to enable functional and molecular imaging. This review focuses on new developments for in vivo small animal micro-CT using novel nanoparticle probes applied in preclinical research. | |
| dc.identifier | ||
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Frontiers Media SA | |
| dc.relation.ispartof | Front Pharmacol | |
| dc.relation.isversionof | 10.3389/fphar.2015.00256 | |
| dc.subject | contrast agents | |
| dc.subject | micro-CT | |
| dc.subject | nanoparticles | |
| dc.subject | small animal imaging | |
| dc.subject | spectral imaging | |
| dc.title | In vivo small animal micro-CT using nanoparticle contrast agents. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Badea, Cristian T|0000-0002-1850-2522 | |
| pubs.author-url | ||
| pubs.begin-page | 256 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biomedical Engineering | |
| pubs.organisational-group | Cell Biology | |
| pubs.organisational-group | Chemistry | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Mechanical Engineering and Materials Science | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | Radiology | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.publication-status | Published online | |
| pubs.volume | 6 |
Files
Original bundle
- Name:
- fphar-06-00256.pdf
- Size:
- 9.26 MB
- Format:
- Adobe Portable Document Format
- Description:
- Published version