Epigenetics of Hypertensive Nephropathy.

dc.contributor.author

Zhang, Yize

dc.contributor.author

Arzaghi, Hamidreza

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Ma, Zhehan

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Roye, Yasmin

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Musah, Samira

dc.date.accessioned

2024-12-29T06:33:35Z

dc.date.available

2024-12-29T06:33:35Z

dc.date.issued

2024-11

dc.description.abstract

Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), contributing to significant morbidity, mortality, and rising healthcare costs. In this review article, we explore the role of epigenetic mechanisms in HN progression and their potential therapeutic implications. We begin by examining key epigenetic modifications-DNA methylation, histone modifications, and non-coding RNAs-observed in kidney disease. Next, we discuss the underlying pathophysiology of HN and highlight current in vitro and in vivo models used to study the condition. Finally, we compare various types of HN-induced renal injury and their associated epigenetic mechanisms with those observed in other kidney injury models, drawing inferences on potential epigenetic therapies for HN. The information gathered in this work indicate that epigenetic mechanisms can drive the progression of HN by regulating key molecular signaling pathways involved in renal damage and fibrosis. The limitations of Renin-Angiotensin-Aldosterone System (RAAS) inhibitors underscore the need for alternative treatments targeting epigenetic pathways. This review emphasizes the importance of further research into the epigenetic regulation of HN to develop more effective therapies and preventive strategies. Identifying novel epigenetic markers could provide new therapeutic opportunities for managing CKD and reducing the burden of ESRD.

dc.identifier

biomedicines12112622

dc.identifier.issn

2227-9059

dc.identifier.issn

2227-9059

dc.identifier.uri

https://hdl.handle.net/10161/31818

dc.language

eng

dc.publisher

MDPI AG

dc.relation.ispartof

Biomedicines

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10.3390/biomedicines12112622

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

epigenetic therapeutics

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epigenetics of disease

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hypertensive nephropathy

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kidney disease

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kidney glomerulus

dc.title

Epigenetics of Hypertensive Nephropathy.

dc.type

Journal article

pubs.begin-page

2622

pubs.issue

11

pubs.organisational-group

Duke

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Pratt School of Engineering

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School of Medicine

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Cell Biology

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Biomedical Engineering

pubs.organisational-group

Medicine

pubs.organisational-group

Medicine, Nephrology

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Duke Cancer Institute

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Duke Regeneration Center

pubs.publication-status

Published

pubs.volume

12

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