An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention.

Abstract

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

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Citation

Published Version (Please cite this version)

10.3389/fnhum.2021.618626

Publication Info

Zaer, Hamed, Ashlesha Deshmukh, Dariusz Orlowski, Wei Fan, Pierre-Hugues Prouvot, Andreas Nørgaard Glud, Morten Bjørn Jensen, Esben Schjødt Worm, et al. (2021). An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention. Frontiers in human neuroscience, 15. p. 618626. 10.3389/fnhum.2021.618626 Retrieved from https://hdl.handle.net/10161/28710.

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Scholars@Duke

Morizio

James Morizio

Adjunct Professor in the Department of Electrical and Computer Engineering

Over the last three decades Dr. Morizio's research has been focused on exploring new analog CMOS microelectronics and systems for cross discipline research areas. One objective of his research is to provide disruptive sensor interface technology in niche applications areas to significantly improve system performance and capabilities beyond their current level of technology integration. These current research areas include wireless neural interface systems for closed loop in vivo electrophysiology instrumentation and highly efficient broadband transducer drivers for scalable ultrasonic microfluidic interfaces. 

Dr. Morizio also has 35 years experience at Duke University teaching analog and digital VLSI circuit design courses and is the co-inventor of 8 issued patents.


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