Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.

Nooner, Kate B

Mennes, Maarten

Brown, Shaquanna

Castellanos, F Xavier

Leventhal, Bennett

Milham, Michael P

Colcombe, Stanley J

United States

2017-01-28T23:39:04Z

2013-12

In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.

http://www.ncbi.nlm.nih.gov/pubmed/24343754

1573-6598

https://hdl.handle.net/10161/13514

eng

Wiley

J Trauma Stress

10.1002/jts.21873

Adaptation, Psychological

Adolescent

Amygdala

Female

Humans

Magnetic Resonance Imaging

Male

Mental Health

Psychiatric Status Rating Scales

Self Report

Stress Disorders, Post-Traumatic

Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/24343754

784

787

6

Clinical Science Departments

Duke

Psychiatry, Child & Family Mental Health and Developmental Neuroscience

Psychiatry & Behavioral Sciences

School of Medicine

Published

26