Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.
Date
2013-12
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Abstract
In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.
Type
Department
Description
Provenance
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Nooner, Kate B, Maarten Mennes, Shaquanna Brown, F Xavier Castellanos, Bennett Leventhal, Michael P Milham and Stanley J Colcombe (2013). Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents. J Trauma Stress, 26(6). pp. 784–787. 10.1002/jts.21873 Retrieved from https://hdl.handle.net/10161/13514.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
Kate B Nooner
Dr. Kate Brody Nooner, PhD, ABPP, has NIH-funded research and collaborates with Dr. David Goldston at Duke Psychiatry as part of the National Consortium on Alcohol & Neurodevelopment in Adolescence. She is also a tenured full Professor, Senior Associate Dean for the College of Science and Engineering, and former Department Chair of the Department of Psychology at the University of North Carolina Wilmington.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.