Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.


In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.





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Publication Info

Nooner, Kate B, Maarten Mennes, Shaquanna Brown, F Xavier Castellanos, Bennett Leventhal, Michael P Milham and Stanley J Colcombe (2013). Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents. J Trauma Stress, 26(6). pp. 784–787. 10.1002/jts.21873 Retrieved from

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Kate B Nooner

Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences

Dr. Kate Brody Nooner, PhD, ABPP, has NIH-funded research and collaborates with Dr. David Goldston at Duke Psychiatry as part of the National Consortium on Alcohol & Neurodevelopment in Adolescence. She is also a tenured full Professor, Associate Dean for the College of Science and Engineering, and former Department Chair of the Department of Psychology at the University of North Carolina Wilmington.

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