SOCE and STIM1 signaling in the heart: Timing and location matter.

Loading...
Thumbnail Image

Date

2019-01

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

0
views
6
downloads

Citation Stats

Abstract

Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in STIM1 and Orai1, the two SOCE components. Here, we consider the evidence for STIM1 and SOCE in cardiac muscle and the sinoatrial node. We highlight recent studies revealing a role for STIM1 in cardiac growth in response to developmental and pathologic cues. We also review the role of STIM1 in the regulation of SOCE and Ca2+ store refilling in a non-Orai dependent manner. Finally, we discuss the importance of this pathway in ventricular cardiomyocytes where SOCE contribute to developmental growth and in pacemaker cells where SOCE likely has a fundamental to generating the cardiac rhythm.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1016/j.ceca.2018.11.008

Publication Info

Rosenberg, Paul, Danielle Katz and Victoria Bryson (2019). SOCE and STIM1 signaling in the heart: Timing and location matter. Cell calcium, 77. pp. 20–28. 10.1016/j.ceca.2018.11.008 Retrieved from https://hdl.handle.net/10161/30121.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.