Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration

dc.contributor.author

Rezvani, AH

dc.contributor.author

Levin, ED

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Wells, C

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Slade, S

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Morrison, M

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Marshall, L

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Morris, M

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Confino, J

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Allenby, C

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Lumeng, L

dc.date.accessioned

2016-12-01T16:09:57Z

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2016-01-01

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© 2016 Amir H. Rezvani et al.Background. Alcohol and nicotine are commonly coabused. The search for a common core of neural, behavioral, and genetic factors underlying addiction has been the goal of addiction research. Purpose. Genetic predisposition to high alcohol intake has been studied in rats by selectively breeding rats that have high preference for alcohol. The current experiments were conducted to determine if the level of intravenous nicotine administration for the various lines of alcohol-preferring rats differs from that for nonalcohol-preferring controls. Study design. Adult alcohol-naïve selectively-bred alcohol-preferring male rats from four lines (P, AA, HAD-1, sP) and their control nonalcohol-preferring rats (NP, ANA, LAD-1, sNP) were trained and given access to self-administer nicotine (0.03mg/kg/infusion). Results. The results show that the P rats selfadministered significantly more nicotine than NP rats. In contrast, there were no significant differences in nicotine self-administration between the sP and sNP or the AA and ANA rats. Unexpectedly, high alcohol-drinking HAD-1 rats self-administered significantly less nicotine than low alcohol-drinking LAD-1 rats. Conclusion. This suggests that some genetic factors that underlie high-alcohol intake have more general effects in promoting high nicotine intake tendencies, while other genetic factors are more specific to only heavy drinking.

dc.identifier.eissn

2090-8342

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2090-8334

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https://hdl.handle.net/10161/13071

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Ashdin Publishing

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Journal of Drug and Alcohol Research

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10.4303/jdar/235972

dc.title

Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration

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Journal article

duke.contributor.orcid

Levin, ED|0000-0002-5060-9602

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5

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Basic Science Departments

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Duke

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Duke Cancer Institute

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Duke Institute for Brain Sciences

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Duke Science & Society

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Environmental Sciences and Policy

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Initiatives

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Institutes and Centers

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Institutes and Provost's Academic Units

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Nicholas School of the Environment

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Pharmacology & Cancer Biology

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Psychiatry & Behavioral Sciences

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Psychiatry & Behavioral Sciences, Addictions

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Psychology and Neuroscience

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School of Medicine

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Trinity College of Arts & Sciences

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University Institutes and Centers

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Published

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2016

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