Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.

Abstract

This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1097/qad.0000000000000386

Publication Info

Palmer, Christine D, Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B Arnold, Denise Che, Douglas A Lauffenburger, Stephanie Jost, et al. (2014). Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. AIDS (London, England), 28(14). pp. 2162–2166. 10.1097/qad.0000000000000386 Retrieved from https://hdl.handle.net/10161/30022.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.