Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.


This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.





Published Version (Please cite this version)


Publication Info

Palmer, Christine D, Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B Arnold, Denise Che, Douglas A Lauffenburger, Stephanie Jost, et al. (2014). Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. AIDS (London, England), 28(14). pp. 2162–2166. 10.1097/qad.0000000000000386 Retrieved from https://hdl.handle.net/10161/30022.

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Stephanie Rachel Jost

Associate Professor in Surgery

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