Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.
| dc.contributor.author | Palmer, Christine D | |
| dc.contributor.author | Tomassilli, Julia | |
| dc.contributor.author | Sirignano, Michael | |
| dc.contributor.author | Romero-Tejeda, Marisol | |
| dc.contributor.author | Arnold, Kelly B | |
| dc.contributor.author | Che, Denise | |
| dc.contributor.author | Lauffenburger, Douglas A | |
| dc.contributor.author | Jost, Stephanie | |
| dc.contributor.author | Allen, Todd | |
| dc.contributor.author | Mayer, Kenneth H | |
| dc.contributor.author | Altfeld, Marcus | |
| dc.date.accessioned | 2024-02-01T15:43:04Z | |
| dc.date.available | 2024-02-01T15:43:04Z | |
| dc.date.issued | 2014-09 | |
| dc.description.abstract | This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition. | |
| dc.identifier.issn | 0269-9370 | |
| dc.identifier.issn | 1473-5571 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
| dc.relation.ispartof | AIDS (London, England) | |
| dc.relation.isversionof | 10.1097/qad.0000000000000386 | |
| dc.rights.uri | ||
| dc.subject | CD4-Positive T-Lymphocytes | |
| dc.subject | CD8-Positive T-Lymphocytes | |
| dc.subject | T-Lymphocytes, Cytotoxic | |
| dc.subject | Humans | |
| dc.subject | HIV-1 | |
| dc.subject | Endotoxemia | |
| dc.subject | Lymphocyte Activation | |
| dc.subject | Homosexuality, Male | |
| dc.subject | HIV Seronegativity | |
| dc.subject | Immunity, Cellular | |
| dc.subject | Male | |
| dc.subject | CD57 Antigens | |
| dc.title | Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Jost, Stephanie|0000-0003-2100-3262 | |
| pubs.begin-page | 2162 | |
| pubs.end-page | 2166 | |
| pubs.issue | 14 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Surgery, Surgical Sciences | |
| pubs.publication-status | Published | |
| pubs.volume | 28 |
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