Occult <i>Talaromyces marneffei</i> Infection Unveiled by the Novel Mp1p Antigen Detection Assay.


Talaromyces marneffei causes fatal invasive mycosis in Southeast Asia. Diagnosis by culture has limited sensitivity and can result in treatment delay. We describe the use of a novel Mp1p enzyme immunoassay (EIA) to identify blood culture-negative talaromycosis, subsequently confirmed by bone marrow cultures. This EIA has the potential to speed diagnosis, enabling early therapy initiation.





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Publication Info

Ly, Vo Trieu, Nguyen Tat Thanh, Nguyen Thi Mai Thu, Jasper Chan, Jeremy N Day, John Perfect, Cao Ngoc Nga, Nguyen Van Vinh Chau, et al. (2020). Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay. Open forum infectious diseases, 7(11). p. ofaa502. 10.1093/ofid/ofaa502 Retrieved from https://hdl.handle.net/10161/23602.

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John Robert Perfect

James B. Duke Distinguished Professor of Medicine

Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.


Thuy Le

Associate Professor of Medicine

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