The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.
Abstract
The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience
calls for an acceleration of discovery and the delineation of developmental trajectories
for risk and resilience across the lifespan. To attain these objectives, sufficiently
powered datasets with broad and deep phenotypic characterization, state-of-the-art
neuroimaging, and genetic samples must be generated and made openly available to the
scientific community. The enhanced Nathan Kline Institute-Rockland Sample (NKI-RS)
is a response to this need. NKI-RS is an ongoing, institutionally centered endeavor
aimed at creating a large-scale (N > 1000), deeply phenotyped, community-ascertained,
lifespan sample (ages 6-85 years old) with advanced neuroimaging and genetics. These
data will be publically shared, openly, and prospectively (i.e., on a weekly basis).
Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling
considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally,
we describe our process for sharing the data with the scientific community while protecting
participant confidentiality, maintaining an adequate database, and certifying data
integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing,
imaging, and sharing data, is discussed while also explaining how this experience
informed the final design of the enhanced NKI-RS. It is our hope that familiarity
with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization
with future data collection efforts aimed at advancing psychiatric neuroscience and
nosology.
Type
Journal articlePermalink
https://hdl.handle.net/10161/13516Published Version (Please cite this version)
10.3389/fnins.2012.00152Publication Info
Nooner, Kate Brody; Colcombe, Stanley J; Tobe, Russell H; Mennes, Maarten; Benedict,
Melissa M; Moreno, Alexis L; ... Milham, Michael P (2012). The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in
Psychiatry. Front Neurosci, 6. pp. 152. 10.3389/fnins.2012.00152. Retrieved from https://hdl.handle.net/10161/13516.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Kate B Nooner
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Dr. Kate Brody Nooner has NIH-funded research and collaborates with Dr. David Goldston
at Duke to conduct research as part of the National Consortium on Alcohol & Neurodevelopment
in Adolescence. She is also a tenured full Professor in the Department of Psychology
at the University of North Carolina Wilmington.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info