The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.
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The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be generated and made openly available to the scientific community. The enhanced Nathan Kline Institute-Rockland Sample (NKI-RS) is a response to this need. NKI-RS is an ongoing, institutionally centered endeavor aimed at creating a large-scale (N > 1000), deeply phenotyped, community-ascertained, lifespan sample (ages 6-85 years old) with advanced neuroimaging and genetics. These data will be publically shared, openly, and prospectively (i.e., on a weekly basis). Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally, we describe our process for sharing the data with the scientific community while protecting participant confidentiality, maintaining an adequate database, and certifying data integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing, imaging, and sharing data, is discussed while also explaining how this experience informed the final design of the enhanced NKI-RS. It is our hope that familiarity with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization with future data collection efforts aimed at advancing psychiatric neuroscience and nosology.
Published Version (Please cite this version)10.3389/fnins.2012.00152
Publication InfoAdelsberg, S; Anwar, AR; Bangaru, S; Benedict, MM; Biswal, B; Brown, S; ... Zavitz, ST (2012). The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry. Front Neurosci, 6. pp. 152. 10.3389/fnins.2012.00152. Retrieved from http://hdl.handle.net/10161/13516.
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Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Dr. Kate Brody Nooner has NIH-funded research and collaborates with Dr. Michael De Bellis at Duke to conduct research as part of the National Consortium on Alcohol & Neurodevelopment in Adolescence. She is also a tenured Associate Professor in the Psychology Department at the University of North Carolina Wilmington.
Visiting Assistant Professor in the Department of Political Science
Alphabetical list of authors with Scholars@Duke profiles.