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Heart rate variability is associated with survival in patients with brain metastasis: a preliminary report.

dc.contributor.author Wang, Y-M
dc.contributor.author Wu, Hau-Tieng
dc.contributor.author Huang, E-Y
dc.contributor.author Kou, YR
dc.contributor.author Hseu, S-S
dc.coverage.spatial United States
dc.date.accessioned 2017-10-04T01:30:44Z
dc.date.available 2017-10-04T01:30:44Z
dc.date.issued 2013
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/24102056
dc.identifier.uri https://hdl.handle.net/10161/15617
dc.description.abstract Impaired heart rate variability (HRV) has been demonstrated as a negative survival prognosticator in various diseases. We conducted this prospective study to evaluate how HRV affects brain metastasis (BM) patients. Fifty-one BM patients who had not undergone previous brain operation or radiotherapy (RT) were recruited from January 2010 to July 2012, and 40 patients were included in the final analysis. A 5-minute electrocardiogram was obtained before whole brain radiotherapy. Time domain indices of HRV were compared with other clinical factors on overall survival (OS). In the univariate analysis, Karnofsky performance status (KPS) <70 (P = 0.002) and standard deviation of the normal-to-normal interval (SDNN) <10 ms (P = 0.004) significantly predict poor survival. The multivariate analysis revealed that KPS <70 and SDNN <10 ms were independent negative prognosticators for survival in BM patients with hazard ratios of 2.657 and 2.204, respectively. In conclusion, HRV is associated with survival and may be a novel prognostic factor for BM patients.
dc.language eng
dc.relation.ispartof Biomed Res Int
dc.relation.isversionof 10.1155/2013/503421
dc.subject Adult
dc.subject Aged
dc.subject Brain Neoplasms
dc.subject Electrocardiography
dc.subject Female
dc.subject Heart Rate
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasms
dc.subject Prognosis
dc.subject Proportional Hazards Models
dc.subject Survival Analysis
dc.title Heart rate variability is associated with survival in patients with brain metastasis: a preliminary report.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/24102056
pubs.begin-page 503421
pubs.organisational-group Duke
pubs.organisational-group Mathematics
pubs.organisational-group Statistical Science
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 2013
dc.identifier.eissn 2314-6141


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