In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.

Date
2017-07
Authors
Jackson, W
Hornik, CP
Messina, JA
Guglielmo, K
Watwe, A
Delancy, G
Valdez, A
MacArthur, T
Peter-Wohl, S
Smith, PB
Tolia, VN
Laughon, MM
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Abstract
OBJECTIVE:To characterize in-hospital outcomes of premature infants diagnosed with severe bronchopulmonary dysplasia (BPD). STUDY DESIGN:Retrospective cohort study including premature infants with severe BPD discharged from 348 Pediatrix Medical Group neonatal intensive care units from 1997 to 2015. RESULTS:There were 10 752 infants with severe BPD, and 549/10 752 (5%) died before discharge. Infants who died were more likely to be male, small for gestational age, have received more medical interventions and more frequently diagnosed with surgical necrotizing enterocolitis, culture-proven sepsis and pulmonary hypertension following 36 weeks of postmenstrual age compared with survivors. Approximately 70% of infants with severe BPD were discharged by 44 weeks of postmenstrual age, and 86% were discharged by 48 weeks of postmenstrual age. CONCLUSIONS:A majority of infants diagnosed with severe BPD were discharged home by 44 weeks of postmenstrual age. These results may inform discussions with families regarding the expected hospital course of infants diagnosed with severe BPD.
Type
Journal article
Subject
Humans
Sepsis
Enterocolitis, Necrotizing
Bronchopulmonary Dysplasia
Hypertension, Pulmonary
Patient Discharge
Risk Factors
Retrospective Studies
Sex Factors
Gestational Age
Infant
Infant, Newborn
Infant, Small for Gestational Age
Intensive Care Units, Neonatal
North Carolina
Female
Male
Infant, Extremely Low Birth Weight
Electronic Health Records
Infant, Extremely Premature
Permalink
https://hdl.handle.net/10161/18165
Published Version (Please cite this version)
10.1038/jp.2017.49
Publication Info
Jackson, W; Hornik, CP; Messina, JA; Guglielmo, K; Watwe, A; Delancy, G; ... Laughon, MM (2017). In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia. Journal of perinatology : official journal of the California Perinatal Association, 37(7). pp. 853-856. 10.1038/jp.2017.49. Retrieved from https://hdl.handle.net/10161/18165.
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Scholars@Duke

Hornik

Christoph Paul Vincent Hornik

Associate Professor of Pediatrics
Messina

Julia Antoinette Messina

Assistant Professor of Medicine
I am a Transplant Infectious Diseases Physician who specializes in the care of immunocompromised patients including solid organ and bone marrow transplant recipients and patients with HIV. My research interest is in the role of the gut microbiome in clinical outcomes in patients with hematologic malignancies.
Smith

Phillip Brian Smith

Samuel L. Katz Distinguished Professor of Pediatrics
Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine at Duke University Medical Center in 2004 and 2007, respectively. He completed an MHS in clinical research from Duke University in 2006 and an MPH in biostatistics from the University of North Carolina at Chapel Hill in 2009. His research is focused on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal infections. Dr. Smith is or has been the protocol chair for more than 14 studie
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