In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.
Abstract
OBJECTIVE:To characterize in-hospital outcomes of premature infants diagnosed with
severe bronchopulmonary dysplasia (BPD). STUDY DESIGN:Retrospective cohort study including
premature infants with severe BPD discharged from 348 Pediatrix Medical Group neonatal
intensive care units from 1997 to 2015. RESULTS:There were 10 752 infants with severe
BPD, and 549/10 752 (5%) died before discharge. Infants who died were more likely
to be male, small for gestational age, have received more medical interventions and
more frequently diagnosed with surgical necrotizing enterocolitis, culture-proven
sepsis and pulmonary hypertension following 36 weeks of postmenstrual age compared
with survivors. Approximately 70% of infants with severe BPD were discharged by 44
weeks of postmenstrual age, and 86% were discharged by 48 weeks of postmenstrual age.
CONCLUSIONS:A majority of infants diagnosed with severe BPD were discharged home by
44 weeks of postmenstrual age. These results may inform discussions with families
regarding the expected hospital course of infants diagnosed with severe BPD.
Type
Journal articleSubject
HumansSepsis
Enterocolitis, Necrotizing
Bronchopulmonary Dysplasia
Hypertension, Pulmonary
Patient Discharge
Risk Factors
Retrospective Studies
Sex Factors
Gestational Age
Infant
Infant, Newborn
Infant, Small for Gestational Age
Intensive Care Units, Neonatal
North Carolina
Female
Male
Infant, Extremely Low Birth Weight
Electronic Health Records
Infant, Extremely Premature
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https://hdl.handle.net/10161/18165Published Version (Please cite this version)
10.1038/jp.2017.49Publication Info
Jackson, W; Hornik, CP; Messina, JA; Guglielmo, K; Watwe, A; Delancy, G; ... Laughon,
MM (2017). In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal Association, 37(7). pp. 853-856. 10.1038/jp.2017.49. Retrieved from https://hdl.handle.net/10161/18165.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Christoph Paul Vincent Hornik
Associate Professor of Pediatrics
Julia Antoinette Messina
Assistant Professor of Medicine
I am a Transplant Infectious Diseases Physician who specializes in the care of immunocompromised
patients including solid organ and bone marrow transplant recipients and patients
with HIV. My research interest is in the role of the gut microbiome in clinical outcomes
in patients with hematologic malignancies.
Phillip Brian Smith
Samuel L. Katz Distinguished Professor of Pediatrics
Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine
at Duke University Medical Center in 2004 and 2007, respectively. He completed an
MHS in clinical research from Duke University in 2006 and an MPH in biostatistics
from the University of North Carolina at Chapel Hill in 2009. His research is focused
on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal
infections. Dr. Smith is or has been the protocol chair for more than 14 studie
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