KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells.
Abstract
The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated
in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific
glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing,
proteostasis and stress resistance in both normal and cancer cells.
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Journal articlePermalink
https://hdl.handle.net/10161/19693Published Version (Please cite this version)
10.1080/23723556.2017.1361501Publication Info
(2017). KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox
stress signaling in cancer cells. Molecular & cellular oncology, 4(6). pp. e1361501. 10.1080/23723556.2017.1361501. Retrieved from https://hdl.handle.net/10161/19693.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Michael Scott Boyce
Associate Professor of Biochemistry
The Boyce Lab studies mammalian cell signaling through protein glycosylation. For
the latest news, project information and publications from our group, please visit
our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.
Jen-Tsan Ashley Chi
Professor in Molecular Genetics and Mirobiology
We are using functional genomic approaches to investigate the nutrient signaling and
stress adaptations of cancer cells when exposed to various nutrient deprivations and
microenvironmental stress conditions. Recently, we focus on two areas. First, we are
elucidating the genetic determinants and disease relevance of ferroptosis, a newly
recognized form of cell death. Second, we have identified the mammalian stringent
response pathway which is highly similar to bacterial stringent response, but
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