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Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.

dc.contributor.author Olson, Lyra B
dc.contributor.author Naqvi, Ibtehaj A
dc.contributor.author Turner, Daniel J
dc.contributor.author Morrison, Sarah A
dc.contributor.author Kraft, Bryan D
dc.contributor.author Chen, Lingye
dc.contributor.author Sullenger, Bruce A
dc.contributor.author Nair, Smita K
dc.contributor.author Que, Loretta G
dc.contributor.author Levy, Jerrold H
dc.date.accessioned 2021-04-01T13:38:58Z
dc.date.available 2021-04-01T13:38:58Z
dc.date.issued 2021-03-30
dc.identifier 02054229-202104000-00009
dc.identifier.issn 2575-3126
dc.identifier.issn 2575-3126
dc.identifier.uri https://hdl.handle.net/10161/22473
dc.description.abstract The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We report a 53-year-old man presenting with acute leukemia and COVID-19 who developed thrombotic complications and acute respiratory distress syndrome. Multiple analyses, including rotational thromboelastometry and flow cytometry on blood and bronchoalveolar lavage, are reported to characterize coagulation and immune profiles. The patient developed chemotherapy-induced neutropenia that may have protected his lungs from granulocyte-driven hyperinflammatory acute lung injury. However, neutropenia also alters viral clearing, potentially enabling ongoing viral propagation. This case depicts a precarious equilibrium between leukemia and COVID-19.
dc.language eng
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartof A&A practice
dc.relation.isversionof 10.1213/xaa.0000000000001432
dc.title Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.
dc.type Journal article
duke.contributor.id Kraft, Bryan D|0437411
duke.contributor.id Sullenger, Bruce A|0112702
duke.contributor.id Nair, Smita K|0114773
duke.contributor.id Que, Loretta G|0113664
duke.contributor.id Levy, Jerrold H|0609832
dc.date.updated 2021-04-01T13:38:57Z
pubs.begin-page e01432
pubs.issue 4
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery, Cardiovascular and Thoracic Surgery
pubs.organisational-group Anesthesiology, Cardiothoracic
pubs.organisational-group Duke
pubs.organisational-group Surgery
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Anesthesiology
pubs.publication-status Published
pubs.volume 15
duke.contributor.orcid Nair, Smita K|0000-0001-7019-1912
duke.contributor.orcid Levy, Jerrold H|0000-0003-3766-4962


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