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Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring

dc.contributor.author Vidal, AC
dc.contributor.author Murphy, SK
dc.contributor.author Murtha, AP
dc.contributor.author Schildkraut, JM
dc.contributor.author Soubry, A
dc.contributor.author Huang, Z
dc.contributor.author Neelon, SEB
dc.contributor.author Fuemmeler, B
dc.contributor.author Iversen, E
dc.contributor.author Wang, F
dc.contributor.author Kurtzberg, J
dc.contributor.author Jirtle, RL
dc.contributor.author Hoyo, C
dc.date.accessioned 2022-03-23T19:40:52Z
dc.date.available 2022-03-23T19:40:52Z
dc.date.issued 2013
dc.identifier.issn 0307-0565
dc.identifier.uri https://hdl.handle.net/10161/24664
dc.description.abstract Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposure to antibiotics may also increase the risk of LBW. The mechanisms underlying this association are unknown, although epigenetic mechanisms are hypothesized. In this study, we evaluated the association between maternal antibiotic use and LBW and examined the potential role of altered DNA methylation that controls growth regulatory imprinted genes in these associations. Methods: Between 2009-2011, 397 pregnant women were enrolled and followed until delivery. Prenatal antibiotic use was ascertained through maternal self-report. Imprinted genes methylation levels were measured at differentially methylated regions (DMRs) using bisulfite pyrosequencing. Generalized linear models were used to examine associations among antibiotic use, birth weight and DMR methylation fractions. Results: After adjusting for infant gender, race/ethnicity, maternal body mass index, delivery route, gestational weight gain, gestational age at delivery, folic acid intake, physical activity, maternal smoking and parity, antibiotic use during pregnancy was associated with 138 g lower birth weight compared with non-antibiotic use (β-coefficient=-132.99, s.e.=50.70, P=0.008). These associations were strongest in newborns of women who reported antibiotic use other than penicillins (β-coefficient=-135.57, s.e.=57.38, P=0.02). Methylation at five DMRs, IGF2 (P=0.05), H19 (P=0.15), PLAGL1 (P=0.01), MEG3 (P=0.006) and PEG3 (P=0.08), was associated with maternal antibiotic use; among these, only methylation at the PLAGL1 DMR was also associated with birth weight. Conclusion: We report an inverse association between in utero exposure to antibiotics and lower infant birth weight and provide the first empirical evidence supporting imprinted gene plasticity in these associations. © 2013 Macmillan Publishers Limited.
dc.relation.ispartof International Journal of Obesity
dc.relation.isversionof 10.1038/ijo.2013.47
dc.title Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring
dc.type Journal article
duke.contributor.id Murphy, SK|0218826
duke.contributor.id Murtha, AP|0097193
duke.contributor.id Schildkraut, JM|0098467
duke.contributor.id Neelon, SEB|0515637
duke.contributor.id Fuemmeler, B|0380453
duke.contributor.id Iversen, E|0136275
duke.contributor.id Kurtzberg, J|0097203
duke.contributor.id Hoyo, C|0295388
dc.date.updated 2022-03-23T19:40:51Z
pubs.begin-page 907
pubs.end-page 913
pubs.issue 7
pubs.organisational-group Duke
pubs.organisational-group Nicholas School of the Environment
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group Faculty
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Institutes and Centers
pubs.organisational-group Family Medicine and Community Health
pubs.organisational-group Pathology
pubs.organisational-group Pediatrics
pubs.organisational-group Family Medicine and Community Health, Prevention Research
pubs.organisational-group Pediatrics, Primary Care Pediatrics
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Statistical Science
pubs.organisational-group Environmental Sciences and Policy
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Initiatives
pubs.organisational-group Center for Child and Family Policy
pubs.organisational-group Duke Innovation & Entrepreneurship
pubs.organisational-group Pediatrics, Transplant and Cellular Therapy
pubs.volume 37
duke.contributor.orcid Murphy, SK|0000-0001-8298-7272
duke.contributor.orcid Kurtzberg, J|0000-0002-3370-0703


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