dc.contributor.author |
Vidal, AC |
|
dc.contributor.author |
Murphy, SK |
|
dc.contributor.author |
Murtha, AP |
|
dc.contributor.author |
Schildkraut, JM |
|
dc.contributor.author |
Soubry, A |
|
dc.contributor.author |
Huang, Z |
|
dc.contributor.author |
Neelon, SEB |
|
dc.contributor.author |
Fuemmeler, B |
|
dc.contributor.author |
Iversen, E |
|
dc.contributor.author |
Wang, F |
|
dc.contributor.author |
Kurtzberg, J |
|
dc.contributor.author |
Jirtle, RL |
|
dc.contributor.author |
Hoyo, C |
|
dc.date.accessioned |
2022-03-23T19:40:52Z |
|
dc.date.available |
2022-03-23T19:40:52Z |
|
dc.date.issued |
2013 |
|
dc.identifier.issn |
0307-0565 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/24664 |
|
dc.description.abstract |
Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic
diseases, including obesity, cardiovascular disease, type II diabetes and some cancers.
The etiology of LBW is multi-factorial. However, recent evidence suggests exposure
to antibiotics may also increase the risk of LBW. The mechanisms underlying this association
are unknown, although epigenetic mechanisms are hypothesized. In this study, we evaluated
the association between maternal antibiotic use and LBW and examined the potential
role of altered DNA methylation that controls growth regulatory imprinted genes in
these associations. Methods: Between 2009-2011, 397 pregnant women were enrolled and
followed until delivery. Prenatal antibiotic use was ascertained through maternal
self-report. Imprinted genes methylation levels were measured at differentially methylated
regions (DMRs) using bisulfite pyrosequencing. Generalized linear models were used
to examine associations among antibiotic use, birth weight and DMR methylation fractions.
Results: After adjusting for infant gender, race/ethnicity, maternal body mass index,
delivery route, gestational weight gain, gestational age at delivery, folic acid intake,
physical activity, maternal smoking and parity, antibiotic use during pregnancy was
associated with 138 g lower birth weight compared with non-antibiotic use (β-coefficient=-132.99,
s.e.=50.70, P=0.008). These associations were strongest in newborns of women who reported
antibiotic use other than penicillins (β-coefficient=-135.57, s.e.=57.38, P=0.02).
Methylation at five DMRs, IGF2 (P=0.05), H19 (P=0.15), PLAGL1 (P=0.01), MEG3 (P=0.006)
and PEG3 (P=0.08), was associated with maternal antibiotic use; among these, only
methylation at the PLAGL1 DMR was also associated with birth weight. Conclusion: We
report an inverse association between in utero exposure to antibiotics and lower infant
birth weight and provide the first empirical evidence supporting imprinted gene plasticity
in these associations. © 2013 Macmillan Publishers Limited.
|
|
dc.relation.ispartof |
International Journal of Obesity |
|
dc.relation.isversionof |
10.1038/ijo.2013.47 |
|
dc.title |
Associations between antibiotic exposure during pregnancy, birth weight and aberrant
methylation at imprinted genes among offspring
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Murphy, SK|0218826 |
|
duke.contributor.id |
Murtha, AP|0097193 |
|
duke.contributor.id |
Schildkraut, JM|0098467 |
|
duke.contributor.id |
Neelon, SEB|0515637 |
|
duke.contributor.id |
Fuemmeler, B|0380453 |
|
duke.contributor.id |
Iversen, E|0136275 |
|
duke.contributor.id |
Kurtzberg, J|0097203 |
|
duke.contributor.id |
Hoyo, C|0295388 |
|
dc.date.updated |
2022-03-23T19:40:51Z |
|
pubs.begin-page |
907 |
|
pubs.end-page |
913 |
|
pubs.issue |
7 |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Nicholas School of the Environment |
|
pubs.organisational-group |
Sanford School of Public Policy |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.organisational-group |
Faculty |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Family Medicine and Community Health |
|
pubs.organisational-group |
Pathology |
|
pubs.organisational-group |
Pediatrics |
|
pubs.organisational-group |
Family Medicine and Community Health, Prevention Research |
|
pubs.organisational-group |
Pediatrics, Primary Care Pediatrics |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Statistical Science |
|
pubs.organisational-group |
Environmental Sciences and Policy |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Initiatives |
|
pubs.organisational-group |
Center for Child and Family Policy |
|
pubs.organisational-group |
Duke Innovation & Entrepreneurship |
|
pubs.organisational-group |
Pediatrics, Transplant and Cellular Therapy |
|
pubs.volume |
37 |
|
duke.contributor.orcid |
Murphy, SK|0000-0001-8298-7272 |
|
duke.contributor.orcid |
Kurtzberg, J|0000-0002-3370-0703 |
|